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Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China

文献类型：期刊论文

作者Yang, Ruchang3,4; Li, Zhe3; Zhu, Yingzhao3,4; Wu, Yuxuan3,4; Lu, Xinchuan3; Zhao, Xueli3; Liu, Junjun2; Du, Xiangdong3,4; Zhang, Xiangyang1
刊名BMC PSYCHIATRY
出版日期2024-06-04
卷号24期号:1页码:9
关键词Major depressive disorder Thyroid-stimulating hormone(TSH) Psychotic symptom First episode Drug naive
DOI10.1186/s12888-024-05860-7
通讯作者Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Introduction Psychotic depression (PD) is characterized by the co-occurrence of emotional dysfunction and psychotic symptoms such as delusions and hallucinations with poor clinical outcomes. TSH may involve in the development of PD. This study aims to explore relationship between TSH and PD. Methods A total of 1718 outpatients diagnosed as FEDN MDD were recruited in this study. The relationship between PD and TSH was evaluated using multivariable binary logistic regression analysis. To assess the presence of non-linear associations, a two-piecewise linear regression model was employed. Furthermore, interaction and stratified analyses were conducted with respect to sex, education, marital status, comorbid anxiety, and suicide attempt. Results Multivariable logistic regression analysis revealed that TSH was positively associated with the risk of PD after adjusting for confounders (OR = 1.26, 95% CI: 1.11 to 1.43; p < 0.05). Smoothing plots showed a nonlinear relationship between TSH and PD, with the inflection point of TSH being 4.94 mIU/L. On the right of the inflection point, for each unit increase in serum TSH level on the right side of the inflection point, the probability of PD increased substantially by 47% (OR = 1.47, 95% CI: 1.25 to 1.73, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 0.87, 95% CI: 0.67 to 1.14, p = 0.32). Conclusion Our investigation showed a nonlinear TSH-PD relationship in FEDN MDD patients, thus contributing to effective intervention strategies for psychotic symptoms in depression patients.
收录类别SCI
WOS关键词THYROID-FUNCTION ; PREVALENCE ; FEATURES ; ILLNESS ; SEROTONIN
资助项目Suzhou Gusu Health Talents Scientific Research Project ; Shanxi Medical University
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001239285700010
出版者BMC
资助机构Suzhou Gusu Health Talents Scientific Research Project ; Shanxi Medical University
源URL[http://ir.psych.ac.cn/handle/311026/48091]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Du, Xiangdong; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Nanjing Meishan Hosp, Nanjing, Peoples R China
3.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China
4.Soochow Univ, Suzhou Med Coll, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Ruchang,Li, Zhe,Zhu, Yingzhao,et al. Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China[J]. BMC PSYCHIATRY,2024,24(1):9.
APA Yang, Ruchang.,Li, Zhe.,Zhu, Yingzhao.,Wu, Yuxuan.,Lu, Xinchuan.,...&Zhang, Xiangyang.(2024).Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China.BMC PSYCHIATRY,24(1),9.
MLA Yang, Ruchang,et al."Non-linear relationship between TSH and psychotic symptoms on first episode and drug na?ve major depressive disorder patients: a large sample sized cross-sectional study in China".BMC PSYCHIATRY 24.1(2024):9.

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来源：心理研究所

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