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Multimodal covarying brain patterns mediate genetic and psychological contributions to individual differences in pain sensitivity

文献类型：期刊论文

作者Zhang, Huijuan7,8; Zhao, Lei7,8; Lu, Xuejing7,8; Peng, Weiwei6; Zhang, Li5; Zhang, Zhiguo3,4; Hu, Li7,8; Cao, Jin2; Tu, Yiheng1,7,8
刊名PAIN
出版日期2024-05-01
卷号165期号:5页码:1074-1085
关键词Pain sensitivity Fatty acid amide hydrolase Pain catastrophizing Sensory-discriminative component Cognitive and emotional components MRI
ISSN号0304-3959
DOI10.1097/j.pain.0000000000003103
通讯作者Tu, Yiheng(yihengtu@gmail.com)
英文摘要Supplemental Digital Content is Available in the Text.Two distinct covarying structural and functional brain patterns mediate gene rs4141964 and pain catastrophizing contributions to individual differences in pain threshold and tolerance, respectively. Individuals vary significantly in their pain sensitivity, with contributions from the brain, genes, and psychological factors. However, a multidimensional model integrating these factors is lacking due to their complex interactions. To address this, we measured pain sensitivity (ie, pain threshold and pain tolerance) using the cold pressor test, collected magnetic resonance imaging (MRI) data and genetic data, and evaluated psychological factors (ie, pain catastrophizing, pain-related fear, and pain-related anxiety) from 450 healthy participants with both sexes (160 male, 290 female). Using multimodal MRI fusion methods, we identified 2 pairs of covarying structural and functional brain patterns associated with pain threshold and tolerance, respectively. These patterns primarily involved regions related to self-awareness, sensory-discriminative, cognitive-evaluative, motion preparation and execution, and emotional aspects of pain. Notably, pain catastrophizing was negatively correlated with pain tolerance, and this relationship was mediated by the multimodal covarying brain patterns in male participants only. Furthermore, we identified an association between the single-nucleotide polymorphism rs4141964 within the fatty acid amide hydrolase gene and pain threshold, mediated by the identified multimodal covarying brain patterns across all participants. In summary, we suggested a model that integrates the brain, genes, and psychological factors to elucidate their role in shaping interindividual variations in pain sensitivity, highlighting the important contribution of the multimodal covarying brain patterns as important biological mediators in the associations between genes/psychological factors and pain sensitivity.
收录类别SCI
WOS关键词SIMPLIFIED CHINESE VERSION ; ANXIETY SYMPTOMS SCALE ; INDEPENDENT COMPONENTS ; CATASTROPHIZING SCALE ; LOW-BACK ; MODULATION ; ATTENTION ; NETWORK ; FEAR ; HERITABILITY
资助项目The STI-2030 Major Project[2022ZD0206400] ; National Natural Science Foundation of China[32200901] ; National Natural Science Foundation of China[32171078] ; National Natural Science Foundation of China[32322035] ; China Postdoctoral Science Foundation[2022M723363] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E0CX52] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4015] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX6815CX]
WOS研究方向Anesthesiology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:001233772300018
出版者LIPPINCOTT WILLIAMS & WILKINS
资助机构The STI-2030 Major Project ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/48097]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Tu, Yiheng
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China
3.Peng Cheng Lab, Shenzhen, Peoples R China
4.Harbin Inst Technol, Sch Comp Sci & Technol, Shenzhen, Peoples R China
5.Shenzhen Univ, Sch Biomed Engn, Med Sch, Shenzhen, Peoples R China
6.Shenzhen Univ, Sch Psychol, Shenzhen, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Huijuan,Zhao, Lei,Lu, Xuejing,et al. Multimodal covarying brain patterns mediate genetic and psychological contributions to individual differences in pain sensitivity[J]. PAIN,2024,165(5):1074-1085.
APA Zhang, Huijuan.,Zhao, Lei.,Lu, Xuejing.,Peng, Weiwei.,Zhang, Li.,...&Tu, Yiheng.(2024).Multimodal covarying brain patterns mediate genetic and psychological contributions to individual differences in pain sensitivity.PAIN,165(5),1074-1085.
MLA Zhang, Huijuan,et al."Multimodal covarying brain patterns mediate genetic and psychological contributions to individual differences in pain sensitivity".PAIN 165.5(2024):1074-1085.

入库方式： OAI收割

来源：心理研究所

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