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Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-na?ve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study

文献类型：期刊论文

作者Tian, Xue3; Liu, Xiao-En3; Bai, Fengfeng3; Li, Meijuan3; Qiu, Yuying3; Jiao, Qingyan3; Li, Jie3; Zhang, Xiang-Yang1,2
刊名BRAIN AND BEHAVIOR
出版日期2024-06-01
卷号14期号:6页码:12
关键词major depressive disorder sex differences subclinical hypothyroidism suicide
ISSN号2162-3279
DOI10.1002/brb3.3578
通讯作者Li, Jie(jieli@tjmhc.com) ; Zhang, Xiang-Yang(zhangxy@psych.ac.cn)
英文摘要BackgroundThis study aimed to investigate sex differences in risk factors for suicide attempts in first-episode and drug naive (FEDN) major depressive disorder (MDD) with comorbid subclinical hypothyroidism (SCH).MethodsA total of 1034 FEDN MDD patients with comorbid SCH were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale were used to assess patients' symptoms. Thyroid hormone levels and metabolic parameters were measured.ResultsMDD patients with SCH had a significantly higher risk of suicide attempts than those without SCH (25.4% vs. 12.2%). Logistic regression showed that HAMA score, thyroid stimulating hormone (TSH) levels, and thyroid peroxidase antibody (TPOAb) levels were significantly associated with an increased risk for suicide attempts in both male and female MDD patients comorbid SCH, while low-density lipoprotein cholesterol (LDL-C) was significantly associated with an increased risk for suicide attempts only in male patients, HAMD score and systolic blood pressure were significantly associated with an increased risk for suicide attempts only in female patients.ConclusionSCH comorbidities may increase suicide attempts in MDD patients. Our results showed significant sex differences in clinical and metabolic factors associated with suicide attempts among FEDN MDD patients with comorbid SCH, highlighting appropriate sex-based preventive interventions are needed. SCH comorbidities may increase suicide attempts in MDD patients. Our results showed significant sex differences in clinical and metabolic factors associated with suicide attempts among FEDN MDD patients with comorbid SCH. image
收录类别SCI
WOS关键词LOW SERUM-CHOLESTEROL ; RISK-FACTORS ; GENDER-DIFFERENCES ; DENSITY-LIPOPROTEIN ; THYROID-FUNCTION ; NATURAL-HISTORY ; POPULATION ; PREVALENCE ; SEVERITY ; INDIVIDUALS
资助项目CAS International Cooperation Research Program
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
语种英语
WOS记录号WOS:001239628200001
出版者WILEY
资助机构CAS International Cooperation Research Program
源URL[http://ir.psych.ac.cn/handle/311026/48122]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Li, Jie; Zhang, Xiang-Yang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China
推荐引用方式
GB/T 7714		 Tian, Xue,Liu, Xiao-En,Bai, Fengfeng,et al. Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-na?ve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study[J]. BRAIN AND BEHAVIOR,2024,14(6):12.
APA Tian, Xue.,Liu, Xiao-En.,Bai, Fengfeng.,Li, Meijuan.,Qiu, Yuying.,...&Zhang, Xiang-Yang.(2024).Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-na?ve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study.BRAIN AND BEHAVIOR,14(6),12.
MLA Tian, Xue,et al."Sex differences in correlates of suicide attempts in Chinese Han first-episode and drug-na?ve major depressive disorder with comorbid subclinical hypothyroidism: A cross-sectional study".BRAIN AND BEHAVIOR 14.6(2024):12.

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来源：心理研究所

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