食物成瘾者奖赏加工过程中异常的预测误差信号及其认知神经 机制
文献类型：学位论文
| 作者 | 文雅童 |
| 答辩日期 | 2024-06 |
| 文献子类 | 博士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 李勇辉 |
| 关键词 | 食物成瘾 奖赏加工过程 预测误差 背侧前扣带回 经颅时域干涉刺激 |
| 学位名称 | 理学博士 |
| 学位专业 | 健康心理学 |
| 其他题名 | Abnormal Prediction Error in Reward Processing in Food Addiction and Its Underlying Cognitive Neural Mechanisms |
| 中文摘要 | In recent years, the obesity rate in China has been rising, and food addiction related to overeating is considered to be one of the important causes of obesity. Food addiction refers to the dependence on specific foods (usually foods rich in sugar and fat) that has developed to the point where it is difficult to control itself, showing a series of addiction-like behavioral changes and changes in neural mechanisms, especially the persistence of food cravings in a satiety state. A strong appetite is a sign of overexpectation of reward. Early studies considered only cue responses, suggesting that the essence of food addiction was greater craving for palatable food, but when studies considered the effects of state, it was found that the lack of appetite from hunger to satiety may be related to reward maintenance. These results suggest that further research needs to consider dynamic reward processing and view eating as a process of continuous access to food and adjustment of eating. The process of reward adjustment depends on the prediction error, and the process from hunger to fullness is the process in which the prediction error tends to be negative and the expectation gradually decreases. Based on this, Study 1 aimed to investigate whether lower Feedback-Related Negative (FRN) in food reward processing was associated with higher Stimulus Preceding Negativity (SPN) and the severity of food addiction. The prediction error in reward processing is related to the incorrect function of monitoring the dorsal anterior cingulate cortex, and the low activity of the dorsal anterior cingulate cortex in food addicts leads to the inability to lower expectations during the process of starvation to fullness. Based on the intracranial manifestations of theta oscillation in the dorsal anterior cingulate cortex and the activation associated with monitoring errors, Study 2 aimed to further verify the relationship between food-related FRN and theta in satiety through time-frequency analysis. Recently, the purpose of this study was to verify the effect of the dorsal anterior cingulate cortex in food addicts and change the predictive error signal in reward processing by transcranial temporally interference stimulation (tTIS) in theta band. Participants were recruited online and divided into food addiction group (YFAS > = 3) and healthy control group (YFAS < = 2) according to the Yale food addiction scale (YFAS) symptom score and BMI index, all using an adapted food and money incentive delay task combined with EEG recordings. A total of 54 participants were recruited in the study, including 27 in the food addiction group and 27 in the healthy control group, and there were significant differences in YFAS and BMI scores between the two groups, but there were no significant differences in age, education level, family income, etc. All subjects completed the experimental tasks in a hungry and full state, with an interval of more than one week. Study 2 and Study 1 were the same experimental data, but further time-frequency analysis was performed on FRN signals that differed between healthy groups and food addiction groups. The preprocessed EEG data was decomposed by wavelet transform to calculate the theta frequency bands located in FCz and Fz from 200ms to 400ms after reward feedback. A total of 34 food addicts were recruited and randomly divided into tTIS true stimulation group and pseudostimulation group, with 17 people in each group. There were no significant differences in YFAS and BMI scores and demographic variables between the tTIS true stimulation group and the pseudostimulation group. The experimental process is divided into the pre-test stage, the TI stimulation stage and the post-test stage, and the pre-test and post-test stages complete the experimental task. All participants participated in the experiment in a full stomach, and there was no significant difference in hunger between the two groups. The results of the first study found that there was no significant difference in reward expectation and feedback monitoring of monetary rewards between the two groups, only significant differences in food rewards, and there was a significant moderating effect on hunger or satiety. Compared with healthy people, the food addiction group had higher reward expectations (larger SPN) and lower prediction error signals (smaller FRN) for food cues only in the satiety state, and food addicts had stronger emotional responses to false feedback (larger late positive potential (LPP). Further correlation analysis showed that the amplitude of FRN in the satiety state was negatively correlated with the amplitude of LPP and SPN, respectively, and a smaller FRN could predict the next larger LPP and a larger SPN. In addition, there was a significant correlation between FRN and YFAS for food rewards in satiety. The results showed that the prediction error signal with lower feedback on food reward in satiety was the key to reward processing abnormalities in food addicts, and was related to the severity of food addiction. The results of study 2 show that theta oscillations are induced by both correct prediction (prediction with actual prediction) and wrong prediction (prediction with actual none) after food reward feedback, and the topography distribution of negative prediction errors (subtraction of the two conditions) is at the frontal midline (FCz and Fz), and the window period and topographic distribution of the frequency band oscillation coincide with FRN. Compared with the control group, FMtheta in the food addiction group showed a decreasing trend compared with the control group, but the statistics did not reach a significant level. The results suggest that abnormally low FMtheta in the food addiction group may be related to the inability to monitor and evaluate normally. These results provide evidence for the regulation of the dorsal anterior cingulate cortex by tTIS in the theta band. Study 3 found that there was a difference between the two groups only in food rewards. The FRN amplitude of food reward increased in food addicts after receiving tTIS true stimulation, while there was no significant change in the pseudostimulation group. There were no significant changes in SPN and LPP in either group. The results suggest that the transient change in FRN is not sufficient to cause co-change between SPN and LPP, or that a stable change in FRN and a sufficiently large change in FRN (i.e., after the functional shift of dACC) can bring about changes in SPN and LPP. Follow-up studies need to further explore the possibility of long-term changes in neural mechanisms and neural signal representations caused by multiple regulation. In general, this study systematically explored the abnormal EEG nerve signal representations of food addicts at different stages of reward processing, and found that abnormal negative prediction error signal (FRN) of food reward in satiety state is an important factor leading to abnormally high expectation of food reward (SPN) and high emotional response (LPP) to false feedback, and the size of FRN is related to the severity of food addiction. Furthermore, the results showed that the food-related FRN in the satiety state coincided with the frontal midline theta in the time-frequency domain, and the FRN of food reward could be enhanced by regulating the dorsal anterior cingulate theta, indicating that the reduction of negative prediction error signal may be related to the monitoring error function related to the dorsal anterior cingulate theta oscillation, and at the same time providing new ideas for further clinical intervention research. Overall, this study aims to construct a technical route for the characterization of specific neural signals in food addicts → the regulation of specific signals for changes in related brain regions", which is of great scientific significance for understanding the neural mechanism of food addiction and its clinical application. |
| 英文摘要 | 近年来，我国肥胖率不断上升，其中暴饮暴食相关的食物成瘾被认为是肥胖发生的重要原因之一。食物成瘾（Food Addiction）是指对特定食物（通常是富含 高糖、高脂肪的食物）的依赖性已经发展到难以自我控制的程度，表现出一系列成瘾样的行为学变化和神经机制的变化，特别表现为在饱腹状态下仍然存在对食 物的渴望。强烈的食欲是一种奖赏预期过高的表现。早期研究仅考虑线索反应，认为食物成瘾的本质是对可口食物更渴望；但当研究考虑状态的影响后，发现从 饥饿到饱腹状态的食欲不降低，可能与奖赏维持有关。这些结果提示进一步研究 需要考虑动态奖赏加工，把进食看作一个不断获得食物和调整进食的过程。奖赏调整的过程依靠于预测误差，从饥饿到饱腹的过程是预测误差趋于负，预期逐渐 降低的过程。基于此，研究一旨在探讨食物成瘾者饱腹状态下在食物奖赏加工中负性预测误差信号（Feedback-Related Negative，FRN）较低是否与较高的奖赏预 期信号（Stimulus Preceding Negativity，SPN）有关，以及与食物成瘾严重程度的关系。奖赏加工中的预测误差与背侧前扣带回的监测错误功能有关食物成瘾者 的背侧前扣带回活动低导致不能在从饿到饱的过程中把预期降下来。基于背侧前扣带回与监测错误相关的激活在颅内表现为 theta 振荡，研究二旨在通过时频分 析，进一步验证饱腹状态下食物相关的 FRN 与 theta 之间的关系。近而，研究三通过 theta 频段的经颅时域干涉刺激（tTIS, Temporally Interference Stimulation） 调控背侧前扣带回，旨在验证食物成瘾者背侧前扣带回的作用，并改变奖赏加工 中的预测误差信号。 年来，我国肥胖率不断上升，其中暴饮暴食相关的食物成瘾被认为是肥胖发生的重要原因之一。食物成瘾（Food Addiction）是指对特定食物（通常是富含 高糖、高脂肪的食物）的依赖性已经发展到难以自我控制的程度，表现出一系列成瘾样的行为学变化和神经机制的变化，特别表现为在饱腹状态下仍然存在对食 物的渴望。强烈的食欲是一种奖赏预期过高的表现。早期研究仅考虑线索反应，认为食物成瘾的本质是对可口食物更渴望；但当研究考虑状态的影响后，发现从 饥饿到饱腹状态的食欲不降低，可能与奖赏维持有关。这些结果提示进一步研究 需要考虑动态奖赏加工，把进食看作一个不断获得食物和调整进食的过程。奖赏 调整的过程依靠于预测误差，从饥饿到饱腹的过程是预测误差趋于负，预期逐渐 降低的过程。基于此，研究一旨在探讨食物成瘾者饱腹状态下在食物奖赏加工中负性预测误差信号（Feedback-Related Negative，FRN）较低是否与较高的奖赏预 期信号（Stimulus Preceding Negativity，SPN）有关，以及与食物成瘾严重程度的关系。奖赏加工中的预测误差与背侧前扣带回的监测错误功能有关，食物成瘾者 的背侧前扣带回活动低导致不能在从饿到饱的过程中把预期降下来。基于背侧前 扣带回与监测错误相关的激活在颅内表现为 theta 振荡，研究二旨在通过时频分 析，进一步验证饱腹状态下食物相关的 FRN 与 theta 之间的关系。近而，研究三通过 theta 频段的经颅时域干涉刺激（tTIS, Temporally Interference Stimulation） 调控背侧前扣带回，旨在验证食物成瘾者背侧前扣带回的作用，并改变奖赏加工中的预测误差信号。 年来，我国肥胖率不断上升，其中暴饮暴食相关的食物成瘾被认为是肥胖发生的重要原因之一。食物成瘾（Food Addiction）是指对特定食物（通常是富含 高糖、高脂肪的食物）的依赖性已经发展到难以自我控制的程度，表现出一系列成瘾样的行为学变化和神经机制的变化，特别表现为在饱腹状态下仍然存在对食 物的渴望。强烈的食欲是一种奖赏预期过高的表现。早期研究仅考虑线索反应，认为食物成瘾的本质是对可口食物更渴望；但当研究考虑状态的影响后，发现从 饥饿到饱腹状态的食欲不降低，可能与奖赏维持有关。这些结果提示进一步研究 需要考虑动态奖赏加工，把进食看作一个不断获得食物和调整进食的过程。奖赏 调整的过程依靠于预测误差，从饥饿到饱腹的过程是预测误差趋于负，预期逐渐 降低的过程。基于此，研究一旨在探讨食物成瘾者饱腹状态下在食物奖赏加工中负性预测误差信号（Feedback-Related Negative，FRN）较低是否与较高的奖赏预 期信号（Stimulus Preceding Negativity，SPN）有关，以及与食物成瘾严重程度的关系。奖赏加工中的预测误差与背侧前扣带回的监测错误功能有关，食物成瘾者的背侧前扣带回活动低导致不能在从饿到饱的过程中把预期降下来。基于背侧前 扣带回与监测错误相关的激活在颅内表现为 theta 振荡，研究二旨在通过时频分 析，进一步验证饱腹状态下食物相关的 FRN 与 theta 之间的关系。近而，研究三 通过 theta 频段的经颅时域干涉刺激（tTIS, Temporally Interference Stimulation） 调控背侧前扣带回，旨在验证食物成瘾者背侧前扣带回的作用，并改变奖赏加工中的预测误差信号。 研究二结果发现，在食物奖赏反馈后正确预测（预测有实际有）和错误预测 （预测有实际无）均诱发了 theta 振荡，且负性预测错误（两个条件相减）的地 形分布在额叶中线（FCz、Fz）处，该频段振荡出现的窗口期和地形分布均与 FRN 重合。食物成瘾组在饱腹状态下 FMtheta 与对照组相比存在降低趋势，但统计未 达到显著。结果表明，食物成瘾组在饱腹状态下异常低的 FMtheta 可能和无法正 常进行监测、评估有关。该部分结果为使用 theta 频段的 tTIS 调控背侧前扣带回 提供证据。 研究三结果发现，两组仅在食物奖赏上存在差异。食物成瘾者在接受 tTIS 真 刺激后对食物奖赏的 FRN 幅度增加，而伪刺激组无显著变化。两组在 SPN 和 LPP 上均无显著改变。该结果提示，FRN 的短暂改变还不足以引起 SPN 和 LPP 的共变，或需要 FRN 稳固改变并且 FRN 的改变足够大时——即 dACC 功能转变 后——才能带来 SPN 和 LPP 的变化。后续研究需进一步探讨多次调控带来长期神经机制及神经信号表征改变的可能性。 总的来说，本研究系统性探讨了食物成瘾者的不同奖赏加工阶段异常的脑电神经信号表征，发现饱腹状态下对食物奖赏负性预测误差信号（FRN）异常是导 致对食物奖赏异常高预期（SPN）和对错误反馈较高情绪反应（LPP）的重要因 素，且 FRN 的大小与食物成瘾严重程度相关。进一步结果发现饱腹状态下食物 相关的 FRN 与额中线 theta 在时频域上重合，且能通过调控背侧前扣带回 theta 增强对食物奖赏的 FRN，表明负性预测误差信号的降低可能与背侧前扣带回 theta 振荡相关的监测错误功能有关，同时为进一步的临床干预研究提供新思路。总体而言,本研究旨在构建“食物成瘾者特异性的神经信号表征→调控相关脑区改变特异性信号”的技术路线，对理解食物成瘾的神经机制及其临床应用都具有重要科学意义。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48009]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 推荐引用方式 GB/T 7714 | 文雅童. 食物成瘾者奖赏加工过程中异常的预测误差信号及其认知神经 机制[D]. 中国科学院心理研究所. 中国科学院大学. 2024. |
入库方式： OAI收割
来源：心理研究所
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