Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study
文献类型：期刊论文
| 作者 | Zhao, Lei4,5,6; Bo, Qijing4,5,6; Zhang, Zhifang4,5,6; Li, Feng4,5,6 ; Zhou, Yuan1,2,3; Wang, Chuanyue4,5,6
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| 刊名 | BMC PSYCHIATRY
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| 出版日期 | 2024-06-07 |
| 卷号 | 24期号:1页码:11 |
| 关键词 | Default mode network Precuneus Bipolar disorder Resting-state functional magnetic resonance imaging Spontaneous brain activity abnormalities |
| DOI | 10.1186/s12888-024-05869-y |
| 通讯作者 | Wang, Chuanyue(wcyadyy@163.com) |
| 英文摘要 | Background Theoretical and empirical evidence indicates the critical role of the default mode network (DMN) in the pathophysiology of the bipolar disorder (BD). This study aims to identify the specific brain regions of the DMN that is impaired in patients with BD.Methods A total of 56 patients with BD and 71 healthy controls (HC) underwent resting-state functional magnetic resonance imaging. Three commonly used functional indices, i.e., fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC), were utilized to identify the brain region showing abnormal spontaneous brain activity in patients with BD. Then, this region served as the seed region for resting-state functional connectivity (rsFC) analysis.Results Compared to the HC group, the BD group showed reduced fALFF, ReHo, and DC values in the left precuneus. Moreover, patients exhibited decreased rsFCs within the left precuneus and between the left precuneus and the medial prefrontal cortex. Additionally, there was diminished negative connectivity between the left precuneus and the left putamen, extending to the left insula (putamen/insula). The abnormalities in DMN functional connectivity were confirmed through various analysis strategies.Conclusions Our findings provide convergent evidence for the abnormalities in the DMN, particularly located in the left precuneus. Decreased functional connectivity within the DMN and the reduced anticorrelation between the DMN and the salience network are found in patients with BD. These findings suggest that the DMN is a key aspect for understanding the neural basis of BD, and the altered functional patterns of DMN may be a potential candidate biomarker for diagnosis of BD. |
| 收录类别 | SCI |
| WOS关键词 | FREQUENCY FLUCTUATION ALFF ; FUNCTIONAL CONNECTIVITY ; UNMEDICATED BIPOLAR ; UNIPOLAR DEPRESSION ; SALIENCE NETWORKS ; MENTAL-DISORDERS ; BRAIN ACTIVITY ; BASE-LINE ; PRECUNEUS ; SCALE |
| 资助项目 | Beijing Hospitals Authority Clinical medicine Development of special funding |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001244350200003 |
| 出版者 | BMC |
| 资助机构 | Beijing Hospitals Authority Clinical medicine Development of special funding |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48055]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Wang, Chuanyue |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China 5.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders Ctr Schizophrenia, Beijing Key Lab Mental Disorders, 5 Ankang Lane,Dewai Ave, Beijing 100088, Peoples R China 6.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders Ctr Schizophrenia, Natl Clin Res Ctr Mental Disorders & Beijing Key L, 5 Ankang Lane,Dewai Ave, Beijing 100088, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Lei,Bo, Qijing,Zhang, Zhifang,et al. Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study[J]. BMC PSYCHIATRY,2024,24(1):11. |
| APA | Zhao, Lei,Bo, Qijing,Zhang, Zhifang,Li, Feng,Zhou, Yuan,&Wang, Chuanyue.(2024).Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study.BMC PSYCHIATRY,24(1),11. |
| MLA | Zhao, Lei,et al."Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study".BMC PSYCHIATRY 24.1(2024):11. |
入库方式： OAI收割
来源：心理研究所
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