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Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder

文献类型：期刊论文

作者Hou, Ximan3,4,5,6; Liu, Rui4,5,6; Zhou, Yuan1,2,4,5,6; Guan, Lin4,5,6; Zhou, Jingjing4,5,6; Liu, Jing4,5,6; Liu, Mengqi4,5,6; Yuan, Xiaofei4,5,6; Feng, Yuan4,5,6; Chen, Xu4,5,6
刊名TRANSLATIONAL PSYCHIATRY
出版日期2024-06-12
卷号14期号:1页码:8
ISSN号2158-3188
DOI10.1038/s41398-024-02974-0
通讯作者Chen, Xu(yinuo0311@163.com) ; Yu, Aihong(imaging2008@sina.com)
英文摘要Differences in clinical manifestations and biological underpinnings between Major Depressive Disorder (MDD) onset during adolescence and adulthood have been posited in previous studies, implying an influential role of age of onset (AOO) in the clinical subtyping and therapeutic approaches to MDD. However, direct comparisons between the two cohorts and their age-matched controls have been lacking in extant investigations. In this investigation, 156 volunteers participated, comprising 46 adolescents with MDD (adolescent-onset group), 35 adults with MDD (adult-onset group), 19 healthy adolescents, and 56 healthy adults. Resting-state functional MRI scans were undergone by all participants. Large-scale network analyses were applied. Subsequently, a 2 x 2 ANOVA was employed to analyze the main effects of diagnosis, age, and their interaction effect on functional connectivity (FC). Furthermore, regression analysis was employed to scrutinize the association between anomalous FC and HAMD sub-scores. Increased FC in visual network (VN), limbic network (LN), VN-dorsal attention network (DAN), VN-LN, and LN-Default Mode (DMN) was found in both adolescent-onset and adult-onset MDD; however, the increased FC in DAN and LN were only found in adult-onset MDD and the decreased FC in DAN was only found in adolescent-onset MDD. Additionally, the relationship between HAMD factor 1 anxiety somatization and altered FC of DAN, VN, and VN-DAN was moderated by AOO. In conclusion, shared and distinctive large-scale network alterations in adolescent-onset and adult-onset MDD patients were suggested by our findings, providing valuable contributions towards refining clinical subtyping and treatment approaches for MDD.
收录类别SCI
WOS关键词STATE FUNCTIONAL CONNECTIVITY ; NEURAL CIRCUITS ; BOTTOM-UP ; ATTENTION ; METAANALYSIS ; ANXIETY ; CORTEX ; AGE
资助项目Capital' s Funds for Health Improvement and Research (CFH2024-2-1171)
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001244888800001
出版者SPRINGERNATURE
资助机构Capital' s Funds for Health Improvement and Research (CFH2024-2-1171)
源URL[http://ir.psych.ac.cn/handle/311026/48058]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Chen, Xu; Yu, Aihong
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing, Peoples R China
4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China
6.Capital Med Univ, Beijing Key Lab Mental Disorders, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Hou, Ximan,Liu, Rui,Zhou, Yuan,et al. Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder[J]. TRANSLATIONAL PSYCHIATRY,2024,14(1):8.
APA Hou, Ximan.,Liu, Rui.,Zhou, Yuan.,Guan, Lin.,Zhou, Jingjing.,...&Yu, Aihong.(2024).Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder.TRANSLATIONAL PSYCHIATRY,14(1),8.
MLA Hou, Ximan,et al."Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder".TRANSLATIONAL PSYCHIATRY 14.1(2024):8.

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来源：心理研究所

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