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Depressive symptom trajectories with prolonged rTMS treatment

文献类型：期刊论文

作者Chen, Xiao3,4,5,6,7; Blumberger, Daniel M.2,6; Downar, Jonathan2,6; Middleton, Victoria J.1; Monira, Naima1; Bowman, Jennifer1; Kriske, Joseph1; Kriske, John1; Donachie, Nancy1; Kaster, Tyler S.6
刊名BRAIN STIMULATION
出版日期2024-05-01
卷号17期号:3页码:525-532
关键词Repetitive transcranial magnetic stimulation Major depressive disorder Group -based trajectory modeling Treatment outcome Naturalistic study Bilateral rTMS
ISSN号1935-861X
DOI10.1016/j.brs.2024.04.010
通讯作者Kaster, Tyler S.(tyler.kaster@camh.ca)
英文摘要Background: A prolonged repetitive transcranial magnetic stimulation (rTMS) treatment course could be beneficial for some patients experiencing major depressive episodes (MDE). We identified trajectories of rTMS response in depressive patients who received an extended rTMS treatment course and sought to determine which trajectories achieved the greatest benefit with a prolonged treatment course. Method: We applied group-based trajectory modeling to a naturalistic dataset of depressive patients receiving a prolonged course of sequential bilateral rTMS (up to 51 treatment sessions) to the dorsolateral prefrontal cortex. Trajectories of the PHQ-9 with extended treatment courses were characterized, and we explored the association between baseline clinical characteristics and group membership using multinomial logistic regression. Results: Among the 324 study participants, four trajectories were identified: "linear response, extended course" (N = 73; 22.5 %); "nonresponse" (N = 23; 7.1 %); "slowed response" (N = 159; 49.1 %); "rapid response, standard treatment length" (N = 69; 21.3 %). Only the "linear response, extended course" group showed considerable clinical improvement after receiving additional rTMS treatments. Greater baseline depressive symptoms were associated with linear response and non-response. Conclusion: Our results confirmed the distinctive response trajectories in depressive patients receiving rTMS and further highlighted that prolonged rTMS treatment courses may be beneficial for a subset of patients with higher initial symptom levels and linear early treatment response.
收录类别SCI
WOS关键词TRANSCRANIAL MAGNETIC STIMULATION ; TREATMENT-RESISTANT DEPRESSION ; MAJOR DEPRESSION ; DOUBLE-BLIND ; DISORDER ; EFFICACY ; THERAPY ; SAFETY ; SELF
资助项目Salience Health Solutions ; National Natural Science Foundation of China[32300933] ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences[Y9CX422005] ; Special Research Assistant Program of the Chinese Academy of Sciences[E2CX0624] ; China Scholarship Council (CSC)[202104910248]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001236683700001
出版者ELSEVIER SCIENCE INC
资助机构Salience Health Solutions ; National Natural Science Foundation of China ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Special Research Assistant Program of the Chinese Academy of Sciences ; China Scholarship Council (CSC)
源URL[http://ir.psych.ac.cn/handle/311026/48100]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Kaster, Tyler S.
作者单位1.Salience Hlth Solut, Plano, TX 75024 USA
2.Univ Toronto, Dept Psychiat, Toronto, ON M5T1R8, Canada
3.Chinese Acad Sci, Int Big Data Ctr Depress Res, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
6.Ctr Addict & Mental Hlth, Campbell Family Res Inst, Temerty Ctr Therapeut Brain Intervent, Toronto, ON M6J 1H4, Canada
7.CAS Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Xiao,Blumberger, Daniel M.,Downar, Jonathan,et al. Depressive symptom trajectories with prolonged rTMS treatment[J]. BRAIN STIMULATION,2024,17(3):525-532.
APA Chen, Xiao.,Blumberger, Daniel M..,Downar, Jonathan.,Middleton, Victoria J..,Monira, Naima.,...&Kaster, Tyler S..(2024).Depressive symptom trajectories with prolonged rTMS treatment.BRAIN STIMULATION,17(3),525-532.
MLA Chen, Xiao,et al."Depressive symptom trajectories with prolonged rTMS treatment".BRAIN STIMULATION 17.3(2024):525-532.

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来源：心理研究所

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