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Development and Validation of Paradigms Based on the Global-First Topological Approach for Alzheimer's Disease Severity Staging

文献类型：期刊论文

作者Bian, Zhida7,8,9; Wang, Bo6,8; Wu, Xingqi4,5,7; Wang, Kai1,3,4,5,7; Jiang, Yi2,9
刊名NEUROPSYCHIATRIC DISEASE AND TREATMENT
出版日期2024
卷号20页码:1225-1234
关键词Alzheimer's disease visual perception deficits paradigm working memory perceptual organization
DOI10.2147/NDT.S460421
通讯作者Wang, Kai(wangkai1964@126.com) ; Jiang, Yi(yijiang@psych.ac.cn)
英文摘要Introduction: Conventional methods like patient history, neuropsychological testing, cerebrospinal fluid examination, and magnetic resonance imaging are widely used to diagnose cases in the current clinical setting but are limited in classifying Alzheimer's disease (AD) stages. Patients with AD exhibit visual perception deficits, which may be a potential target to assess the severity of the disease according to visual paradigms. However, owing to the inconsistent forms of perceived objects, the defects of current visual processing paradigms often lead to inconsistent results and a lack of sensitivity and specificity. Methods: We develop two paradigms based on global -first topological approach of visual perception, which avoids inconsistent results and lack of sensitivity and specificity owing to the inconsistent forms of perceived objects in traditional paradigms, delineate a unique detection strategy from perception organization (Experiment 1) and visual working memory (VWM) (Experiment 2). Results: Except for the significant differences of the reaction times (RTs) between groups, significant differences were found when AD subjects recognize small figures due to the consistency of global and local figures in similarity test. The difference of RTs between recognizing global and local figures can be recognized in AD and mild cognitive impairment (MCI) group compared to healthy elderly (HE) in similarity test (Experiment 1). The memory capacity of AD patients was significantly lower than MCI group. Topological interference effect was observed in MCI and HE group, whereas MCI patients may have a greater difference trend in nontopological and topological changes than HE (Experiment 2). Conclusion: Our paradigms provide a new strategy, which can assist clinical severity staging and linking topological approach of visual perception with pathophysiological processes in AD.
收录类别SCI
WOS关键词SHORT-TERM-MEMORY ; ASSOCIATION WORKGROUPS ; DIAGNOSTIC GUIDELINES ; NATIONAL INSTITUTE ; INTERFERENCE ; BINDING ; RECOMMENDATIONS ; DEFICIT ; AGE
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001243450400001
出版者DOVE MEDICAL PRESS LTD
源URL[http://ir.psych.ac.cn/handle/311026/48107]  
专题心理研究所_脑与认知科学国家重点实验室
通讯作者Wang, Kai; Jiang, Yi
作者单位1.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
3.Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Hefei 230032, Peoples R China
4.Collaborat Innovat Ctr Neuropsychiat Disorders & M, Hefei 230022, Peoples R China
5.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei 230022, Peoples R China
6.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
7.Anhui Prov Key Lab Cognit & Neuropsychiat Disorder, Hefei 230022, Peoples R China
8.Hefei Comprehens Natl Sci Ctr, Inst Artificial Intelligence, Hefei 230088, Peoples R China
9.Anhui Med Univ, Sch Basic Med, Hefei 230032, Peoples R China
推荐引用方式
GB/T 7714		 Bian, Zhida,Wang, Bo,Wu, Xingqi,et al. Development and Validation of Paradigms Based on the Global-First Topological Approach for Alzheimer's Disease Severity Staging[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2024,20:1225-1234.
APA Bian, Zhida,Wang, Bo,Wu, Xingqi,Wang, Kai,&Jiang, Yi.(2024).Development and Validation of Paradigms Based on the Global-First Topological Approach for Alzheimer's Disease Severity Staging.NEUROPSYCHIATRIC DISEASE AND TREATMENT,20,1225-1234.
MLA Bian, Zhida,et al."Development and Validation of Paradigms Based on the Global-First Topological Approach for Alzheimer's Disease Severity Staging".NEUROPSYCHIATRIC DISEASE AND TREATMENT 20(2024):1225-1234.

入库方式： OAI收割

来源：心理研究所

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