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Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR-II Fluorescence Imaging

文献类型：期刊论文

作者Zeng, Fanwei1,2; Li, Changjian3,4; Wang, Han1,2; Wang, Yueqi5; Ren, Tingting1,2; He, Fangzhou1,2; Jiang, Jie1,2; Xu, Jiuhui1,2; Wang, Boyang1,2; Wu, Yifan1,2
刊名ADVANCED SCIENCE
出版日期2024-03-19
页码15
关键词intraoperative fluorescence-guided surgery near-infrared imaging osteosarcoma targeted probe
DOI10.1002/advs.202310167
通讯作者Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Wang, Shidong(stonewang@bjmu.edu.cn) ; Tang, Xiaodong(tang15877@126.com)
英文摘要Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and blurry tumor boundaries. Besides, intraoperative frozen-section analysis of resection margins of OS is often restricted by the hard tissues around OS, which makes it impossible to know whether a negative margin is achieved. Any unresected small tumor residuals will lead to local recurrence and worse prognosis. Herein, based on the high expression of B7H3 in OS, a targeted probe B7H3-IRDye800CW is synthesized by conjugating anti-B7H3 antibody and IRDye800CW. B7H3-IRDye800CW can accurately label OS areas after intravenous administration, thereby helping surgeons identify and resect residual OS lesions (<2 mm) and lung metastatic lesions. The tumor-background ratio reaches 4.42 +/- 1.77 at day 3. After incubating fresh human OS specimen with B7H3-IRDye800CW, it can specifically label the OS area and even the microinvasion area (confirmed by hematoxylin-eosin [HE] staining). The probe labeled area is consistent with the tumor area shown by magnetic resonance imaging and complete HE staining of the specimen. In summary, B7H3-IRDye800CW has translational potential in intraoperative resection guidance and rapid pathological diagnosis of OS.
WOS关键词GUIDED SURGERY ; SINGLE-CENTER ; CANCER ; TUMOR ; SURVIVAL ; PANITUMUMAB-IRDYE800CW ; THERAPY ; SAFETY ; CELLS ; BONE
资助项目National Natural Science Foundation of China ; Beijing Natural Science Foundation[7232193] ; Fundamental Research Funds for the Central Universities[JKF-YG-22-B005] ; [82373140] ; [81972509] ; [62027901]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001187296100001
出版者WILEY
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities
源URL[http://ir.ia.ac.cn/handle/173211/57882]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Tian, Jie; Wang, Shidong; Tang, Xiaodong
作者单位1.Peking Univ, Dept Musculoskeletal Tumor, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Beijing Key Lab Musculoskeletal Tumor, Peoples Hosp, Beijing 100044, Peoples R China
3.Beihang Univ, Sch Engn Med, Minist Ind & Informat Technol, Beijing 100191, Peoples R China
4.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol, Beijing 100191, Peoples R China
5.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zeng, Fanwei,Li, Changjian,Wang, Han,et al. Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR-II Fluorescence Imaging[J]. ADVANCED SCIENCE,2024:15.
APA Zeng, Fanwei.,Li, Changjian.,Wang, Han.,Wang, Yueqi.,Ren, Tingting.,...&Tang, Xiaodong.(2024).Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR-II Fluorescence Imaging.ADVANCED SCIENCE,15.
MLA Zeng, Fanwei,et al."Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR-II Fluorescence Imaging".ADVANCED SCIENCE (2024):15.

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来源：自动化研究所

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