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Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging

文献类型：期刊论文

作者Tian, Yaqi1,2; Shen, Hongliang3; Li, Lingbing2,4; Jia, Xiaohua2; Liu, Jin1; Hu, Zhenhua2,5; Wang, Liang1; Tian, Jie2,5,6
刊名EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
出版日期2024-04-22
页码14
关键词Prostate cancer Fluorescence Surgery Molecular imaging Second near-infrared window
ISSN号1619-7070
DOI10.1007/s00259-024-06714-w
通讯作者Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Wang, Liang(1311935212@qq.com) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Purpose One of the main reasons for prostate cancer (PCa) recurrence is the difficulty in identifying and removing cancerous lesions during surgery. Accurately localizing and excising cancerous tissue remains a significant challenge. The second near-infrared window (NIR-II, 1000-1700 nm) fluorescence offers enhanced resolution, a high signal-to-noise ratio, and the potential for deeper tissue penetration. However, this technology is not currently employed for intraoperative imaging of PCa. This study aims to construct a new NIR-II probe targeting B7-H3 (Ab(B7-H3)-800CW) for accurate intraoperative identification and resection of PCa. Methods Based on the differential expression of B7-H3 in PCa, we designed a novel imaging probe to accurately identify and guide the resection of preclinical PCa models and ex vivo human PCa tissues using NIR-II fluorescence imaging technology. Results Analyzing tissue samples from 60 clinical cases of PCa, along with benign prostatic hyperplasia and normal prostate tissue from 22 cases, we observed a significant difference in B7-H3 protein expression levels (P < 0.001). Subcutaneous and orthotopic mouse models of PCa were imaged using NIR-II fluorescence after Ab(B7-H3)-800CW injection, showing promising results with successful tumor targeting and high-contrast images achieved within 24-48 h post-injection. The imaging also enabled the detection of occult PCa lesions approximately 1 mm in diameter. In addition, imaging analysis of human PCa and adjacent tissues using Ab(B7-H3)-800CW incubation revealed that cancer tissues exhibited a significantly higher fluorescence intensity than adjacent tissues (P < 0.05), which was conducive to the evaluation of tumor resection margin in vitro. Conclusion The findings revealed that B7-H3 was a compelling imaging target for PCa. The Ab(B7-H3)-800CW molecular imaging probe is capable of accurately identifying PCa lesions and guiding their removal. This approach can potentially reduce the rate of surgical margins under NIR-II fluorescence guidance.
WOS关键词FLUORESCENCE ; EXPRESSION ; SURGERY
资助项目National Natural Science Foundation of China
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:001206258900001
出版者SPRINGER
资助机构National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/58291]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hu, Zhenhua; Wang, Liang; Tian, Jie
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, 95 Yongan Rd, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
3.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Intervent Radiol Dept, Beijing, Peoples R China
5.Natl Key Lab Kidney Dis, Beijing, Peoples R China
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data based Precis Med, Sch Engn Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Tian, Yaqi,Shen, Hongliang,Li, Lingbing,et al. Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2024:14.
APA Tian, Yaqi.,Shen, Hongliang.,Li, Lingbing.,Jia, Xiaohua.,Liu, Jin.,...&Tian, Jie.(2024).Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,14.
MLA Tian, Yaqi,et al."Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2024):14.

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来源：自动化研究所

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