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Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study

文献类型：期刊论文

作者Zhi, Dongmei2; Jiang, Rongtao3; Pearlson, Godfrey4; Fu, Zening5,6; Qi, Shile7; Yan, Weizheng8; Feng, Aichen1,9,10; Xu, Ming1,9,10; Calhoun, Vince5,6; Sui, Jing2,5,6
刊名BIOLOGICAL PSYCHIATRY
出版日期2024-05-01
卷号95期号:9页码:828-838
ISSN号0006-3223
DOI10.1016/j.biopsych.2023.12.019
通讯作者Calhoun, Vince(vince.calhoun@ece.gatech.edu) ; Sui, Jing(kittysj@gmail.com)
英文摘要BACKGROUND: Environmental exposures play a crucial role in shaping children's behavioral development. However, the mechanisms by which these exposures interact with brain functional connectivity and influence behavior remain unexplored. METHODS: We investigated the comprehensive environment-brain-behavior triple interactions through rigorous association, prediction, and mediation analyses, while adjusting for multiple confounders. Particularly, we examined the predictive power of brain functional network connectivity (FNC) and 41 environmental exposures for 23 behaviors related to cognitive ability and mental health in 7655 children selected from the Adolescent Brain Cognitive Development (ABCD) Study at both baseline and follow-up. RESULTS: FNC demonstrated more predictability for cognitive abilities than for mental health, with cross-validation from the UK Biobank study (N = 20,852), highlighting the importance of thalamus and hippocampus in longitudinal prediction, while FNC1environment demonstrated more predictive power than FNC in both cross-sectional and longitudinal prediction of all behaviors, especially for mental health (r = 0.32-0.63). We found that family and neighborhood exposures were common critical environmental influencers on cognitive ability and mental health, which can be mediated by FNC significantly. Healthy perinatal development was a unique protective factor for higher cognitive ability, whereas sleep problems, family conflicts, and adverse school environments specifically increased risk of poor mental health. CONCLUSIONS: This work revealed comprehensive environment-brain-behavior triple interactions based on the ABCD Study, identified cognitive control and default mode networks as the most predictive functional networks for a wide repertoire of behaviors, and underscored the long-lasting impact of critical environmental exposures on childhood development, in which sleep problems were the most prominent factors affecting mental health.
WOS关键词SOCIOECONOMIC-STATUS ; FAMILY INCOME ; CHILDHOOD ; RISK ; ASSOCIATION ; ATTENTION ; PATTERNS ; EXPOSURE
资助项目Scientific and Technological Innovation 2030 grant[2021ZD0200500] ; Natural Science Foundation of China[62373062] ; Natural Science Foundation of China[82022035] ; China Postdoctoral Science Foundation[2022M710434] ; National Institutes of Health[R01EB005846] ; National Institutes of Health[R01MH117107] ; National Institutes of Health[R01MH118695] ; National Science Foundation[2112455]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:001227269700001
出版者ELSEVIER SCIENCE INC
资助机构Scientific and Technological Innovation 2030 grant ; Natural Science Foundation of China ; China Postdoctoral Science Foundation ; National Institutes of Health ; National Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/58451]  
专题自动化研究所_脑网络组研究中心
通讯作者Calhoun, Vince; Sui, Jing
作者单位1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
3.Yale Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT USA
4.Yale Sch Med, Dept Psychiat & Neurobiol, New Haven, CT USA
5.Emory Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30307 USA
6.Georgia State Univ, Atlanta, GA 30302 USA
7.Nanjing Univ Aeronaut & Astronaut, Coll Comp Sci & Technol, Nanjing, Peoples R China
8.NIH, Natl Inst Alcohol Abuse & Alcoholism, Lab Neuroimaging, Bethesda, MD USA
9.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhi, Dongmei,Jiang, Rongtao,Pearlson, Godfrey,et al. Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study[J]. BIOLOGICAL PSYCHIATRY,2024,95(9):828-838.
APA Zhi, Dongmei.,Jiang, Rongtao.,Pearlson, Godfrey.,Fu, Zening.,Qi, Shile.,...&Sui, Jing.(2024).Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study.BIOLOGICAL PSYCHIATRY,95(9),828-838.
MLA Zhi, Dongmei,et al."Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study".BIOLOGICAL PSYCHIATRY 95.9(2024):828-838.

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来源：自动化研究所

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