Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea
文献类型：期刊论文
| 作者 | Lu, Yan1,2,3,4; Liu, Jing5; Li, Bei1,2,3; Wang, Haoyu4 ; Wang, Fangfang4; Wang, Shengxiong4; Wu, Hao1,2,3,4; Han, Hua5,6,7; Hua, Yunfeng1,2,3,4
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| 刊名 | ISCIENCE
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| 出版日期 | 2024-02-16 |
| 卷号 | 27期号:2页码:16 |
| DOI | 10.1016/j.isci.2024.108825 |
| 通讯作者 | Han, Hua(hua.han@ia.ac.cn) ; Hua, Yunfeng(yunfeng.hua@shsmu.edu.cn) |
| 英文摘要 | In the mammalian cochlea, moderate acoustic overexposure leads to loss of ribbon -type synapse between the inner hair cell (IHC) and its postsynaptic spiral ganglion neuron (SGN), causing a reduced dynamic range of hearing but not a permanent threshold elevation. A prevailing view is that such ribbon loss (known as synaptopathy) selectively impacts the low -spontaneous -rate and high -threshold SGN fibers contacting predominantly the modiolar IHC face. However, the spatial pattern of synaptopathy remains scarcely characterized in the most sensitive mid -cochlear region, where two morphological subtypes of IHC with distinct ribbon size gradients coexist. Here, we used volume electron microscopy to investigate noise exposure -related changes in the mouse IHCs with and without ribbon loss. Our quantifications reveal that IHC subtypes differ in the worst -hit area of synaptopathy. Moreover, we show relative enrichment of mitochondria in the surviving SGN terminals, providing key experimental evidence for the longproposed role of SGN-terminal mitochondria in synaptic vulnerability. |
| WOS关键词 | HEARING-LOSS ; SYNAPSES ; EXPOSURE ; ACCELERATION ; SYNAPTOPATHY ; GRADIENTS ; VESICLES ; FIBERS ; TRAUMA ; MICE |
| 资助项目 | National Natural Science Foundation of China[82171133] ; National Natural Science Foundation of China[32171461] ; Industrial Support Fund of Huangpu District in Shanghai[XK2019011] ; Innovative Research Team of High-level Local Universities in Shanghai[SHSMU-ZLCX20211700] ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases[14DZ2260300] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001176174300001 |
| 出版者 | CELL PRESS |
| 资助机构 | National Natural Science Foundation of China ; Industrial Support Fund of Huangpu District in Shanghai ; Innovative Research Team of High-level Local Universities in Shanghai ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases |
| 源URL | [http://ir.ia.ac.cn/handle/173211/57821]  |
| 专题 | 类脑智能研究中心_微观重建与智能分析 |
| 通讯作者 | Han, Hua; Hua, Yunfeng |
| 作者单位 | 1.Shanghai Ninth Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Shanghai 200125q, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Ear Inst, Shanghai 200125, Peoples R China 3.Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai 200125, Peoples R China 4.Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Inst Precis Med, Sch Med, Shanghai 200125, Peoples R China 5.Chinese Acad Sci, Lab Brain Atlas & Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Sch Future Technol, Beijing 101408, Peoples R China 7.Chinese Acad Sci, Inst Automat, State Key Lab Multimodal Artificial Intelligence S, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yan,Liu, Jing,Li, Bei,et al. Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea[J]. ISCIENCE,2024,27(2):16. |
| APA | Lu, Yan.,Liu, Jing.,Li, Bei.,Wang, Haoyu.,Wang, Fangfang.,...&Hua, Yunfeng.(2024).Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea.ISCIENCE,27(2),16. |
| MLA | Lu, Yan,et al."Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea".ISCIENCE 27.2(2024):16. |
入库方式： OAI收割
来源：自动化研究所
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