个体化经颅电刺激的电场模拟研究
文献类型：学位论文
| 作者 | 马炜玮 |
| 答辩日期 | 2024-06 |
| 文献子类 | 硕士 |
| 授予单位 | 中国科学院大学 |
| 授予地点 | 中国科学院心理研究所 |
| 其他责任者 | 涂毅恒 |
| 关键词 | 个体化经颅电刺激 电场 全生命周期曲线 解剖结构因素 头部模型 |
| 学位名称 | 应用心理硕士 |
| 学位专业 | 应用心理 |
| 其他题名 | A Computational Modeling Study of Individualized Transcranial Electrical Stimulation |
| 中文摘要 | Non-invasive neuromodulation via transcranial electrical stimulation (tES) has emerged as a promising tool for various scientific and therapeutic applications due to its safety, availability and portability. TES can modulate brain activity and behavior, but its effects vary across individuals and partially depend on head anatomy. Due to inter-individual variability in head tissues, there exist individual differences in the electric currents reaching the targeted brain regions. Leveraging computational modeling and image reconstruction techniques, our study consists of three substudies investigating how the electric field (EF) of highdefinition tES changes across the lifespan in different demographic groups and how it relates to the neural responses measured by functional magnetic resonance imaging (fMRI) during stimulation. On this basis, we further proposed a possible solution to individualized tES. In Study 1, we used MRI-guided finite element method to simulate EF for the two most common tES montages in two large cohorts of 1616 white and Asian participants in total aged 12 to 100. We found that EF intensity decreased with age, particularly before 25, and was influenced by gender and ethnicity. Interaction effects between age and gender were only found for EF intensity in targeted brain regions in the Asian, but not in the white populations. The focality of tES, on the other hand, diminished with age, except for a slight recovery in the Asian elderly compared to the Asian middle-aged group. Additionally, by examining the head anatomy of each individual, we identified skull thickness, scalp thickness, and subdural cerebrospinal fluid thickness, as the dominant anatomical factors explaining the inter-individual EF variability. The main factors affecting tES focality varied across ethnic groups and different tES montages. Next, using concurrent tES-fMRI approach, we observed a spatial consistency between the simulated EF and the brain activity changes induced by transcranial direct current stimulation in the target region in Study 2. The decreased distances between the site of maximum EF intensity and the site of maximum brain activations in real stimulation group compared to the sham group provided evidence for the immediate neuromodulation effects on local spontaneous brain activity, indicating that tES simulation could reflect tES-induced brain activity changes in the target region. In Study 3, we developed tESview, an open-source toolbox with age-stratified head models intended for efficient EF calculations in both the Asian and white groups. Differentiated by head anatomy of the adolescent cohort and the adult cohort, the head models based on MRI data collected in China are especially fit for the Chinese populations. Our findings characterize and quantify the individual differences in tES- induced EF and offer a reference for conducting individualized neuromodulation. The toolbox we developed is expected to facilitate the implementation of tES personalization and improve the sensitivity of tES-related studies with Chinese participants and the efficacy of tES in Chinese patients. To sum up, our study established age trajectories of EF measures across gender and ethnic groups and revealed key anatomical factors underlying individual differences in EF. We also explored the association between the simulated EF and tES-induced fMRI changes, underlining the need for tES electric field modeling. Ultimately, our study built ready-made head models for the Chinese populations and a toolbox for quick tES modeling, providing beneficial resources for the field of individualized tES. |
| 英文摘要 | 经颅电刺激技术（transcranial electrical stimulation，tES）是一种非侵入性神 经调控手段，因其安全性、实用性和便携性等优势，有望在科学研究和临床治疗中得到广泛应用。tES 对个体的脑活动和行为表现均具有调控作用，但是其调控效果存在较强变异性。原因之一是不同个体的头部解剖结构不同，通过这些结构进入靶向脑区的实际物理电刺激存在个体差异。 基于电场模拟和三维重建的方法，本文共开展了三项研究，考察了不同人口学群体中，高精度 tES 产生的颅内电场的变化规律，初步探索了颅内电场分布和刺激同步功能磁共振成像（functional magnetic resonance imaging，fMRI）记录到的神经响应分布之间的关联，并在此基础上ᨀ出了促进个体化 tES 研究落地的解决方案。 研究一收集了 1616 例白种人和黄种人全生命周期（12~100 岁）的磁共振结构像数据，基于磁共振成像引导的数值模拟方法，探索了两种常用 tES 刺激排布下靶向脑区接受到的物理刺激强度和刺激聚焦性在不同人口学群体间的差异。结果显示，靶向脑区电场强度随年龄增长而降低，且 25 岁前场强随年龄急剧下降。在黄种人中发现靶向脑区的电场强度存在年龄和性别间的交互效应，但未见于白种人。tES 刺激聚焦性则随年龄增长而减弱，仅在黄种人中观察到老年群体的 tES 聚焦性与中年群体相比小幅增强。通过分析头部解剖结构因素，研 究发现影响靶向脑区场强最主要的因素依次为中心电极下的颅骨厚度、头皮厚度和脑脊液厚度，而影响刺激聚焦性的主要因素在不同种族、不同刺激排布间不一致。 研究二关注了 tES 电场分布模拟值与刺激诱导的真实脑响应间的联系，借助 tES 同步脑成像技术，研究记录了在高精度经颅直流电刺激过程中被试的 fMRI 数据，发现电场分布的模拟值和靶向脑区的功能活动分布之间存在空间一致性，即相较于假刺激组，经颅直流电刺激诱发的大脑活动变化最强的位置与电场模拟得到的场强最高点更为接近，ᨀ示模拟得到的最大场强位置一定程度上可以反映脑活动变化最强烈的位置。 研究三编写了基于磁共振成像数据的 tES 电场计算工具 tESview，在数据积累的基础上，以性别、年龄和种族等人口学变量划分人群，有针对性地建立了不同人口学群体的头部模型。特别是，tESview 区分了青少年和成年不同年龄段 群体的头模，并ᨀ供了适用于中国人的 tES 调控模板，帮助中国用户快速计算不同群体、不同刺激排布下 tES 电场分布，为 tES 刺激量的个性化选择ᨀ供参 考。这有望促进个体化 tES 的实施，ᨀ高以中国人为被试的神经调控研究的敏感性和神经调控在中国患者中的疗效。 综上，本研究揭示了高精度 tES 产生的颅内电场在不同人口学群体中的全生命周期曲线以及解释颅内电场变异性的关键头部解剖因素。研究还首次建立了电场模拟值与真实脑功能活动之间的关联，强调了 tES 电场模拟的重要性，并开发了基于中国人头部解剖特性的模型和开源电场计算软件，为个体化 tES 领域ᨀ供了有利资源。 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48144]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 推荐引用方式 GB/T 7714 | 马炜玮. 个体化经颅电刺激的电场模拟研究[D]. 中国科学院心理研究所. 中国科学院大学. 2024. |
入库方式： OAI收割
来源：心理研究所
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