Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation
文献类型：期刊论文
| 作者 | Li,Lei; Yang,Hua-Fei; Ding,Qian-Hui; Wei,Kun; Yang,Yu-Rong |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2023 |
| 关键词 | ASYMMETRIC TOTAL SYNTHESES ALPHA-ALLYLATION FORMAL SYNTHESIS QUININE |
| ISSN号 | 1523-7052 |
| DOI | 10.1021/acs.orglett.3c01659 |
| 英文摘要 | Metallaphotoredox-enableddeoxygenative arylation of alcohols isa recently developed robust synthetic strategy for sp(2)-sp(3) coupling by MacMillan. Inspired by this method, we reportherein its first utilization in natural product total synthesis throughrealizing the coupling of 4-bromo-quinoline or 4-bromo-6-methoxyquinolinewith quincorine or quincoridine, respectively. The alcohols were denovo synthesized in racemic form by a key step of the intramolecularDiels-Alder reaction or in an enantioselective manner by Ir/aminedual-catalyzed allylation. All members of the cinchona alkaloids couldbe prepared efficiently. |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:001006586100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75284]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Li,Lei,Yang,Hua-Fei,Ding,Qian-Hui,et al. Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation[J]. ORGANIC LETTERS,2023. |
| APA | Li,Lei,Yang,Hua-Fei,Ding,Qian-Hui,Wei,Kun,&Yang,Yu-Rong.(2023).Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation.ORGANIC LETTERS. |
| MLA | Li,Lei,et al."Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation".ORGANIC LETTERS (2023). |
入库方式： OAI收割
来源：昆明植物研究所
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