Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla
文献类型：期刊论文
| 作者 | Zhou,Hao-Feng; Li,Wen-Yan; Wu,Qi; Ren,Jian; Peng,Li-Yan; Li,Xiao-Nian; Zhao,Qin-Shi |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2023 |
| 卷号 | 25期号:24页码:4434-4438 |
| 关键词 | ATRIAL INHIBITORS CHANNELS |
| ISSN号 | 1523-7052 |
| DOI | 10.1021/acs.orglett.3c01342 |
| 英文摘要 | Spirophyllines A-D (1-4), four new spirooxindole alkaloids all characterized bythe spiro[pyrrolidin-3,3 '-oxindole]core and a rare isoxazolidine ring, were isolated from Uncariarhynchophylla. Their structures were determined by spectroscopicmethods and confirmed by X-ray crystallography. Based on the biomimeticsemisynthesis strategy, compounds 1-8 were synthesized in three steps via the key reactions of 1,3-dipolarcycloaddition and Krapcho decarboxylation from corynoxeine. Interestingly,compound 3 showed moderate inhibitory activity againstthe K(v)1.5 potassium channel (IC50 = 9.1 mu M). |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:001004393600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75285]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhou,Hao-Feng,Li,Wen-Yan,Wu,Qi,et al. Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla[J]. ORGANIC LETTERS,2023,25(24):4434-4438. |
| APA | Zhou,Hao-Feng.,Li,Wen-Yan.,Wu,Qi.,Ren,Jian.,Peng,Li-Yan.,...&Zhao,Qin-Shi.(2023).Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla.ORGANIC LETTERS,25(24),4434-4438. |
| MLA | Zhou,Hao-Feng,et al."Discovery and Biomimetic Semisynthesis of Spirophyllines A-D from Uncaria rhynchophylla".ORGANIC LETTERS 25.24(2023):4434-4438. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。