Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714
文献类型：期刊论文
| 作者 | He,Xin; Ren,Jinqiu; Wang,Li ; Luo,Jianying; Yang,Jing; Gu,Yu-Cheng; Yan,Yijun; Huang,Sheng-Xiong
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2023 |
| 卷号 | 25期号:10页码:1760-1764 |
| ISSN号 | 1523-7052 |
| DOI | 10.1021/acs.orglett.3c00478 |
| 英文摘要 | Quinolizidomycins A (1) and B (2), two unprecedented quinolizidine alkaloids featuring a tricyclic 6/6/5 ring system, were isolated from Streptomyces sp. KIB-1714. Their structures were assigned by detailed spectroscopic data analyses and X-ray diffraction. Stable isotope labeling experiments suggested that compounds 1 and 2 are derived from lysine, ribose 5-phosphate, and acetate units, which indicates an unprecedented manner of assembly of the quinolizidine (1-azabicyclo[4.4.0]decane) scaffold in quinolizidomycin biosynthesis. Quinolizidomycin A (1) was active in an acetylcholinesterase inhibitory assay. |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:000957722700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75288]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | He,Xin,Ren,Jinqiu,Wang,Li,et al. Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714[J]. ORGANIC LETTERS,2023,25(10):1760-1764. |
| APA | He,Xin.,Ren,Jinqiu.,Wang,Li.,Luo,Jianying.,Yang,Jing.,...&Huang,Sheng-Xiong.(2023).Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714.ORGANIC LETTERS,25(10),1760-1764. |
| MLA | He,Xin,et al."Discovery and Biosynthetic Origin of Quinolizidomycins A and B, Two Quinolizidine Alkaloids from Streptomyces sp. KIB-1714".ORGANIC LETTERS 25.10(2023):1760-1764. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。