Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis
文献类型：期刊论文
| 作者 | Ye,Yan-Song; Duan,Yao-Tao; Zhou,Zhuo ; Thepkaysone,Khamphanh; Douangdeuane,Bounleuane; Xu,Gang
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2023 |
| 卷号 | 86期号:9页码:2206-2215 |
| 关键词 | CAGED XANTHONES CONSTITUENTS INHIBITORS BENZOPHENONES DERIVATIVES BIPHENYL TWIGS |
| ISSN号 | 1520-6025 |
| DOI | 10.1021/acs.jnatprod.3c00498 |
| 英文摘要 | Thirty-five diverse polyphenols, belonging to seven structure classes, were isolated from Garcinia gracilis, a medicinal and edible plant sampled from Laos. The structures of nine new compounds, gargarcilones A-I (1-3, 5-7, 10, 12, and 17), were established using spectroscopic, X-ray diffraction, and experimental and calculated ECD methods. Additionally, we revised the stereochemical assignment of cochinchinoxanthone and cochinchinoxanthone C. The compounds were evaluated for antiproliferative activity against five human tumor cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, and SW480). Compounds 1-4, 7, and 8 exhibited cytotoxic activity with IC50 values of 0.5-8.9 mu M. Compound 3 significantly induced apoptosis in SMMC-7721 cells. |
| WOS记录号 | WOS:001060968500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75292]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Ye,Yan-Song,Duan,Yao-Tao,Zhou,Zhuo,et al. Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(9):2206-2215. |
| APA | Ye,Yan-Song,Duan,Yao-Tao,Zhou,Zhuo,Thepkaysone,Khamphanh,Douangdeuane,Bounleuane,&Xu,Gang.(2023).Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis.JOURNAL OF NATURAL PRODUCTS,86(9),2206-2215. |
| MLA | Ye,Yan-Song,et al."Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis".JOURNAL OF NATURAL PRODUCTS 86.9(2023):2206-2215. |
入库方式： OAI收割
来源：昆明植物研究所
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