Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis
文献类型：期刊论文
| 作者 | Jin,Qiong; Qin,Xu-Jie; Sun,Wen-Jie; Ding,Xiao; Zhao,Yun; Wang,Chang-Bin; Tao,Xing-Yu; Luo,Xiao-Dong
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2023 |
| 卷号 | 86期号:9页码:2193-2205 |
| 关键词 | ACETYLCHOLINESTERASE SEEDS PLANTS |
| ISSN号 | 1520-6025 |
| DOI | 10.1021/acs.jnatprod.3c00493 |
| 英文摘要 | Sixteen new quinolizidine alkaloids (QAs), named ormosianinesA-P(1-16), and 18 known congeners (17-34) were isolated from the stems andleaves of Ormosia yunnanensis. The structures wereelucidated based on spectroscopic analyses and electron circular dichroism(ECD) calculations. Structurally, ormosianines A (1)and B (2) are the first examples of cytisine and Ormosia-type alkaloids with the cleavage of the piperidinering. Results of the acetylcholinesterase (AChE) inhibitory assayrevealed that the pentacycline Ormosia-type QAs,including 1, 16, 24, and 27-29, are good AChE inhibitors. OrmosianineA (1) exhibited more potent AChE inhibitory activitywith an IC50 value of 1.55 & mu;M. Molecular dockingrevealed that 1 might bind to the protein 1DX4, formingtwo hydrogen bonds with residues SER-238 and HIS-480. |
| WOS记录号 | WOS:001050142300001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75293]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Jin,Qiong,Qin,Xu-Jie,Sun,Wen-Jie,et al. Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis[J]. JOURNAL OF NATURAL PRODUCTS,2023,86(9):2193-2205. |
| APA | Jin,Qiong.,Qin,Xu-Jie.,Sun,Wen-Jie.,Ding,Xiao.,Zhao,Yun.,...&Luo,Xiao-Dong.(2023).Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis.JOURNAL OF NATURAL PRODUCTS,86(9),2193-2205. |
| MLA | Jin,Qiong,et al."Ormosianines A-P, Structurally Diverse Quinolizidine Alkaloids with AChE Inhibitory Effects from Ormosia yunnanensis".JOURNAL OF NATURAL PRODUCTS 86.9(2023):2193-2205. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。