Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis
文献类型：期刊论文
| 作者 | Guo,Kai; Zhou,Ting-Ting; Luo,Shi-Hong; Liu,Yan-Chun; Liu,Yan; Li,Sheng-Hong
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 67期号:1页码:513-528 |
| 关键词 | GLANDULAR TRICHOMES PRODUCTS HARBOR CANUM |
| ISSN号 | 1520-4804 |
| DOI | 10.1021/acs.jmedchem.3c01759 |
| 英文摘要 | Intragastric administration of the total sesterterpenoid extract (TSE) of medicinal plant Leucosceptrum canum at 2.5 g/kg dose protected mice from LPS-induced sepsis. Phytochemical investigation led to the isolation and identification of 47 leucosceptrane sesterterpenoids (1-47) including 30 new compounds (1-30) with complicated oxygenation patterns. Biological screening indicated their immunosuppressive activity via inhibiting IFN-gamma secretion and/or proliferation of T cells with different potencies. Mechanism study of compounds 9, 25, and 32 revealed that they inhibited the activations of AKT-mTOR, JNK, p38 MAPK or ERK pathway in T cells and macrophages. In addition, compounds 9 and 25 induced G0/G1 cell arrest of T cells. The major component, leucosceptroid N (32), significantly lowered the levels of IL-6 and TNF-alpha in peripheral blood serum, and ameliorated the multiorgan damages of LPS-induced sepsis mice at 25 mg/kg dose. These findings suggest that leucosceptrane sesterterpenoids are a new type of potential immunosuppressive agents for sepsis treatment. |
| 学科主题 | 193 |
| WOS记录号 | WOS:001141744000001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75295]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Guo,Kai,Zhou,Ting-Ting,Luo,Shi-Hong,et al. Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis[J]. JOURNAL OF MEDICINAL CHEMISTRY,2023,67(1):513-528. |
| APA | Guo,Kai,Zhou,Ting-Ting,Luo,Shi-Hong,Liu,Yan-Chun,Liu,Yan,&Li,Sheng-Hong.(2023).Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis.JOURNAL OF MEDICINAL CHEMISTRY,67(1),513-528. |
| MLA | Guo,Kai,et al."Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis".JOURNAL OF MEDICINAL CHEMISTRY 67.1(2023):513-528. |
入库方式： OAI收割
来源：昆明植物研究所
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