Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca2+/CaMKII and PKA Pathways and Multiple-Enzyme Inhibition
文献类型：期刊论文
| 作者 | Cui,Can; Wu,Sheng-Li; Chen,Ji-Jun ; Gongpan,Pianchou; Guan,Min; Geng,Chang-An
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 71期号:43页码:16148-16159 |
| 关键词 | Alpinia oxyphylla sesquiterpenoids GLP-1 stimulation Ca2+/CaMKII and PKA pathways alpha-glucosidase and PTP1B inhibitory activity |
| ISSN号 | 1520-5118 |
| DOI | 10.1021/acs.jafc.3c06093 |
| 英文摘要 | Six new sesquiterpenoids (1-6), a pair of enantiomers (7a and 7b), and six known ones (8-13) were isolated from the fruits of Alpinia oxyphylla. The structures of the new compounds were elucidated by extensive spectroscopic data and ECD calculations. The stereochemistry of 7a and 7b was reported for the first time. All compounds showed significant GLP-1 stimulation in NCI-H716 cells with promoting ratios ranging from 90.4 to 668.9% at 50 mu M. Mechanism study indicated that compound 6 stimulated GLP-1 secretion mainly by regulating the transcription and the shearing process of proglucagon, while compound 13 exerted its effects through up-regulating prkaca levels. Interestingly, the GLP-1 stimulative effects of 6 and 13 were both closely related with Ca2+/CaMKII and PKA pathways but irrelevant to TGR5 and GPR119 receptors. Moreover, most compounds exhibited inhibitory activity against alpha-glucosidase and PTP1B at concentrations of 100 and 200 mu M, while showing no activity against GPa. Compounds 3, 9, 11, and 13 could suppress alpha-glucosidase with IC50 values of 190.0, 204.0, 181.8, and 159.6 mu M, equivalent to acarbose (IC50 = 212.0 mu M). This study manifests that A. oxyphylla contains diverse sesquiterpenoids with multiple activities. |
| WOS记录号 | WOS:001097005900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75296]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Cui,Can,Wu,Sheng-Li,Chen,Ji-Jun,et al. Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca2+/CaMKII and PKA Pathways and Multiple-Enzyme Inhibition[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(43):16148-16159. |
| APA | Cui,Can,Wu,Sheng-Li,Chen,Ji-Jun,Gongpan,Pianchou,Guan,Min,&Geng,Chang-An.(2023).Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca2+/CaMKII and PKA Pathways and Multiple-Enzyme Inhibition.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(43),16148-16159. |
| MLA | Cui,Can,et al."Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca2+/CaMKII and PKA Pathways and Multiple-Enzyme Inhibition".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.43(2023):16148-16159. |
入库方式： OAI收割
来源：昆明植物研究所
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