UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata
文献类型：期刊论文
| 作者 | Wang,Peng ; Yang,Xiao-Meng; Hu,Zhan-Xing; Li,Ya-Nan; Yang,Jue; Hao,Xiao-Jiang; Yuan,Chun-Mao; Yi,Ping
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2023 |
| 卷号 | 71期号:44页码:16581-16592 |
| 关键词 | Physalis angulata rare withanolidederivatives isolation and identification anticancer anti-inflammatory activity CYTOTOXIC WITHANOLIDES CONSTITUENTS PLANTS L. |
| ISSN号 | 1520-5118 |
| DOI | 10.1021/acs.jafc.3c04311 |
| 英文摘要 | Physalis angulata Linn. is an exotic Amazonian fruit that is commonly recognized as wild tomato, winter cherry, and gooseberry. While its fruit is known to contain many nutrients, such as minerals, fibers, and vitamins, few papers have investigated withanolide derivatives from its fruits. UPLC-Q-Orbitrap-MS/MS, which produces fragmentation spectra, was applied for the first time to guide the isolation of bioactive withanolide derivatives from P. angulata fruits. As a result, twenty-six withanolide derivatives, including two novel 1,10-secowithanolides (1 and 2) and a new derivative (3), were obtained. Compounds 1 and 2 are rare rearranged 1,10-secowithanolides with a tetracyclic 7/6/6/5 ring system. All structures were assigned through various spectroscopic data and quantum chemical calculations. Nine withanolide derivatives exhibited significant inhibitory effects on three tumor cell lines with IC50 values of 0.51-13.79 mu M. Moreover, three new compounds (1-3) exhibited potential nitric oxide inhibitory effects in lipopolysaccharide-stimulated RAW264.7 cells (IC50: 7.51-61.8 mu M). This investigation indicated that fruits of P. angulata could be applied to treat and prevent cancer and inflammatory-related diseases due to their potent active withanolide derivatives. |
| WOS记录号 | WOS:001096867200001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75300]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wang,Peng,Yang,Xiao-Meng,Hu,Zhan-Xing,et al. UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(44):16581-16592. |
| APA | Wang,Peng.,Yang,Xiao-Meng.,Hu,Zhan-Xing.,Li,Ya-Nan.,Yang,Jue.,...&Yi,Ping.(2023).UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(44),16581-16592. |
| MLA | Wang,Peng,et al."UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.44(2023):16581-16592. |
入库方式： OAI收割
来源：昆明植物研究所
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