Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities
文献类型：期刊论文
| 作者 | Yang,Li-Yuan; Yi,Ping; Chen,Jun-Lei; Li,Yu-Huan; Qiu,Jue-Lin; Wang,Zhao-Yang; Fu,Mao; Yuan,Chun-Mao; Huang,Lie-Jun; Hao,Xiao-Jiang
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2023 |
| 关键词 | Primulina eburnea triterpenes flavonoids phenylethanoid glycosides cytotoxic activity GLUCOSIDES LEAVES CELL |
| ISSN号 | 1612-1880 |
| DOI | 10.1002/cbdv.202300248 |
| 英文摘要 | Two new ursane-type triterpenes, eburnealactones A and B (1 and 2), one new flavonoid, eburneatin A (6), and one new phenylethanoid glycoside, chiritoside D (7), along with 9 known compounds (3-5, 8-13) were isolated from the whole plant of Primulina eburnea. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, and HR-ESI-MS). All the compounds were evaluated for their cytotoxic activities. Compound 1 showed significant cytotoxic activities against MKN-45 cell lines and 5637 cell lines with the IC50 values of 9.57 mu M and 8.30 mu M, respectively. Compound 1 exhibited moderate cytotoxic activities against A549 and PATU8988T cell lines with the IC50 values of 30.70 mu M and 38.22 mu M, respectively. Compound 6 exhibited moderate cytotoxic activities against MKN-45, HCT116, PATU8988T, 5637 and A-673 cell lines with the IC50 values of 19.69 mu M, 16.44 mu M, 18.07 mu M, 11.51 mu M and 18.15 mu M, respectively. Compound 5 showed moderate cytotoxic activities against A549 cell lines with the IC50 values of 24.06 mu M. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000981527100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75326]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yang,Li-Yuan,Yi,Ping,Chen,Jun-Lei,et al. Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities[J]. CHEMISTRY & BIODIVERSITY,2023. |
| APA | Yang,Li-Yuan.,Yi,Ping.,Chen,Jun-Lei.,Li,Yu-Huan.,Qiu,Jue-Lin.,...&Gu,Wei.(2023).Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities.CHEMISTRY & BIODIVERSITY. |
| MLA | Yang,Li-Yuan,et al."Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities".CHEMISTRY & BIODIVERSITY (2023). |
入库方式： OAI收割
来源：昆明植物研究所
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