Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells
文献类型：期刊论文
| 作者 | Dong,Lu; Li,Yanpeng; Qin,Fuying; Cheng,Yongxian |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2023 |
| 关键词 | Resina Commiphora germacrane sesquiterpenes cell viability apoptosis PC-3 cells ANTIOXIDANT MYRRHA BERRYI MUKUL |
| ISSN号 | 1612-1880 |
| DOI | 10.1002/cbdv.202300218 |
| 英文摘要 | Four new germacrane-type sesquiterpenes commiphoranes M1-M4 (1-4) together with eighteen sesquiterpenes were isolated from the Resina Commiphora. The structures and relative configurations of new substances were determined by using spectroscopic methods. Biological activity investigation revealed that nine compounds including 7, 9, 14, 16, (+)-17, (-)-17, 18, 19, and 20 could induce the apoptosis of prostate cancer originated PC-3 cells, through classic apoptosis signaling pathway, even using flow cytometry showed that the compound (+)-17 caused apoptosis of PC-3 cells more than 40 %, suggesting their potential therapeutic application in the development of novel drugs against prostate cancer. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000970172700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75327]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Dong,Lu,Li,Yanpeng,Qin,Fuying,et al. Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells[J]. CHEMISTRY & BIODIVERSITY,2023. |
| APA | Dong,Lu,Li,Yanpeng,Qin,Fuying,&Cheng,Yongxian.(2023).Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells.CHEMISTRY & BIODIVERSITY. |
| MLA | Dong,Lu,et al."Sesquiterpenoids from the Resina Commiphora Promoting the Apoptotic Activity of PC-3 Prostate Cancer Cells".CHEMISTRY & BIODIVERSITY (2023). |
入库方式： OAI收割
来源：昆明植物研究所
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