Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
文献类型：期刊论文
| 作者 | Zhang, Hui1,2,4; Dong, Liyun1,2,4; Guo, Tao3; Zhang, Guoqing1; Ye, Xinyue1,2,4; He, Xiaojian2; Gao, Qingfang2; Bello, Mubarak G.3; Peng, Can4; Wu, Li2,3,4 |
| 刊名 | AAPS PHARMSCITECH
 |
| 出版日期 | 2024-06-11 |
| 卷号 | 25期号:5页码:12 |
| 关键词 | lutein molecular docking solubility stability beta-cyclodextrin metal-organic framework |
| ISSN号 | 1530-9932 |
| DOI | 10.1208/s12249-024-02853-3 |
| 通讯作者 | Peng, Can(pengcan@ahtcm.edu.cn) ; Wu, Li(wuli@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular disease. However, enhancements to Lut stability and solubility remain challenges to be addressed in the healthcare industry. Herein, we fabricated and evaluated a food-grade highly porous beta-cyclodextrin metal-organic framework (beta-CD-MOF) for its ability to encapsulate Lut. Lut stability considerably improved when loaded into beta-CD-MOF to form a Lut@beta-CD-MOF complex, which exhibited better stability than Lut loaded into the gamma-cyclodextrin metal-organic framework (Lut@gamma-CD-MOF), Lut@beta-CD, and commercial product (Blackmores (TM)) at 40 degrees C, 60 degrees C, and 70 degrees C, respectively. The solubility of Lut@beta-CD-MOF in water increased by 26.8-fold compared to raw Lut at 37 degrees C. Lut@beta-CD-MOF exhibited greater hydrophilicity, as determined by measuring the water contact angle. Molecular docking and other characterizations of Fourier transform infrared spectroscopy and powder X-ray diffraction confirmed that Lut was successfully encapsulated in the chamber formed by the three cyclodextrins in beta-CD-MOF. Thermogravimetric analysis and Raman spectroscopy demonstrated that Lut distributed in the beta-CD-MOF cavity deeply improved Lut stability and solubility. In conclusion, our findings underscored the function of beta-CD-MOF in enhancing Lut stability and solubility for formulation applications.Graphical AbstractThe helical structure of beta-CD-MOF was instrumental in deeply encapsulating the long-chain Lut molecule, effectively restricting its movement within the structure. This led to a significant improvement in the stability of Lut at 60 degrees C when loaded into beta-CDMOF. Moreover, upon interaction with water, the coordination bonds of beta-CD-MOF were disrupted to facilitate a superior dispersibility of the Lut molecule, leading to a remarkable 26.8-fold increase in solubility compared to raw Lut at 37 degrees C. |
| WOS关键词 | ZEAXANTHIN ; INCLUSION ; BIOAVAILABILITY ; TRANSFORMATION ; ENCAPSULATION ; LYCOPENE ; FORM |
| 资助项目 | National Natural Science Foundation of China[82273863] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001245025200001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311398]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Peng, Can; Wu, Li; Zhang, Jiwen |
| 作者单位 | 1.Jiangsu Yunshi Pharmaceut Technol Co Ltd, Nantong 226000, Peoples R China 2.Yangtze Delta Drug Adv Res Inst, Nantong 226000, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China 4.Anhui Univ Chinese Med, Hefei 230012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hui,Dong, Liyun,Guo, Tao,et al. Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements[J]. AAPS PHARMSCITECH,2024,25(5):12. |
| APA | Zhang, Hui.,Dong, Liyun.,Guo, Tao.,Zhang, Guoqing.,Ye, Xinyue.,...&Zhang, Jiwen.(2024).Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements.AAPS PHARMSCITECH,25(5),12. |
| MLA | Zhang, Hui,et al."Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements".AAPS PHARMSCITECH 25.5(2024):12. |
入库方式： OAI收割
来源：上海药物研究所
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