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Biotransformation of chenodeoxycholic acid by human intestinal fungi and the agonistic effects on FXR

文献类型：期刊论文

作者Wei, Xuemei3,4; Yao, Changliang4; He, Xin4; Li, Jiayuan4; Wang, Yulu4; Wang, Chao2; Chen, Qinhua1; Ma, Xiaochi2; Guo, De-an4
刊名PHYTOCHEMISTRY
出版日期2024-08-01
卷号224页码:10
关键词Chenodeoxycholic acid Biotransformation Intestinal fungi FXR
ISSN号0031-9422
DOI10.1016/j.phytochem.2024.114162
通讯作者Ma, Xiaochi(maxc1978@163.com) ; Guo, De-an(daguo@simm.ac.cn)
英文摘要Bile acids play a vital role in modulating host metabolism, with chenodeoxycholic acid (CDCA) standing out as a primary bile acid that naturally activates farnesoid X receptor (FXR). In this study, we investigated the microbial transformations of CDCA by seven human intestinal fungal species. Our findings revealed that hydroxylation and dehydrogenation were the most prevalent metabolic pathways. Incubation of CDCA with Rhizopus microspores (PT2906) afforded eight undescribed compounds ( 6 - 13 ) alongside five known analogs ( 1 - 5 ) which were elucidated by HRESI-MS and NMR data. Notably, compounds 8 , 12 and 13 exhibited an inhibitory effect on FXR in contrast to the FXR activation observed with CDCA in vitro assays. This study shone a light on the diverse transformations of CDCA by intestinal fungi, unveiling potential modulators of FXR activity with implications for host metabolism.
WOS关键词BILE-ACID ; MICROBIOTA
资助项目Sanming Project of Medicine in Shenzhen[SZZYSM202106004]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001247976000001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/311410]  
专题中国科学院上海药物研究所
通讯作者Ma, Xiaochi; Guo, De-an
作者单位1.Shenzhen Baoan Authent TCM Therapy Hosp, Shenzhen 518101, Peoples R China
2.Dalian Med Univ, Coll Integrat Med, Coll Pharm, Dalian 116044, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharmaceut Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Xuemei,Yao, Changliang,He, Xin,et al. Biotransformation of chenodeoxycholic acid by human intestinal fungi and the agonistic effects on FXR[J]. PHYTOCHEMISTRY,2024,224:10.
APA Wei, Xuemei.,Yao, Changliang.,He, Xin.,Li, Jiayuan.,Wang, Yulu.,...&Guo, De-an.(2024).Biotransformation of chenodeoxycholic acid by human intestinal fungi and the agonistic effects on FXR.PHYTOCHEMISTRY,224,10.
MLA Wei, Xuemei,et al."Biotransformation of chenodeoxycholic acid by human intestinal fungi and the agonistic effects on FXR".PHYTOCHEMISTRY 224(2024):10.

入库方式： OAI收割

来源：上海药物研究所

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