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Rutin Cocrystals with Improved Solubility, Bioavailability, and Bioactivities

文献类型：期刊论文

作者Zhang, Bingrui2,3; Tang, Lei2,3; Tian, Fanyu1; Ding, Qiaoce3; Hu, Ziyi2,3; Wang, Jian-Rong3; Mei, Xuefeng1,2,3
刊名CRYSTAL GROWTH & DESIGN
出版日期2024-06-13
页码11
ISSN号1528-7483
DOI10.1021/acs.cgd.4c00430
通讯作者Wang, Jian-Rong(jrwang@simm.ac.cn) ; Mei, Xuefeng(xuefengmei@simm.ac.cn)
英文摘要Rutin is a natural compound that is widely distributed in various plants. Increasing lines of evidence have proved that rutin has a beneficial effect on cardiovascular health, oxidative stress, and blood glucose control. However, the application of rutin is limited due to its poor solubility and low oral bioavailability. To improve the bioavailability of rutin, two cocrystals of rutin with l-proline and d-proline were prepared successfully, and multiple characterization methods were utilized to study the physicochemical properties of rutin and its cocrystals. The powder dissolution in vitro and the pharmacokinetic behavior in vivo were also evaluated. The results indicated that Rut-l-Pro exhibited a significantly improved solubility, and the oral bioavailability also had great improvement; the AUC(0-10h) of Rut-l-Pro was 5.6-fold that of rutin, and C-max was 3.8 times. As a result of the improvement of rutin bioavailability, Rut-l-Pro performed better blood glucose control and cardioprotective activities.
WOS关键词ANTIOXIDANT ; QUERCETIN ; RATS
资助项目Natural Science Foundation of Shanghai Municipality[43322ZR1473900] ; Shanghai Natural Science Foundation
WOS研究方向Chemistry ; Crystallography ; Materials Science
语种英语
WOS记录号WOS:001247380700001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/311425]  
专题中国科学院上海药物研究所
通讯作者Wang, Jian-Rong; Mei, Xuefeng
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Bingrui,Tang, Lei,Tian, Fanyu,et al. Rutin Cocrystals with Improved Solubility, Bioavailability, and Bioactivities[J]. CRYSTAL GROWTH & DESIGN,2024:11.
APA Zhang, Bingrui.,Tang, Lei.,Tian, Fanyu.,Ding, Qiaoce.,Hu, Ziyi.,...&Mei, Xuefeng.(2024).Rutin Cocrystals with Improved Solubility, Bioavailability, and Bioactivities.CRYSTAL GROWTH & DESIGN,11.
MLA Zhang, Bingrui,et al."Rutin Cocrystals with Improved Solubility, Bioavailability, and Bioactivities".CRYSTAL GROWTH & DESIGN (2024):11.

入库方式： OAI收割

来源：上海药物研究所

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