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Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C-H Activation/[4+2] Cyclization

文献类型：期刊论文

作者Liu, Xueqing3,5; Shi, Sijia3,4; Ding, Wenqian3,5; He, Zhiyue1,2; Shen, Yu4; Nian, Yong4; Wu, Xiaowei1,2,3,5
刊名ORGANIC LETTERS
出版日期2024-06-07
页码5
ISSN号1523-7060
DOI10.1021/acs.orglett.4c01536
通讯作者Nian, Yong(ynian@njucm.edu.cn) ; Wu, Xiaowei(wuxiaowei@simm.ac.cn)
英文摘要Herein, we report a rhodium-catalyzed C-H activation/[4+2] cyclization reaction between alpha,beta-unsaturated amides and iodonium ylides for the synthesis of novel 7,8-dihydroquinoline-2,5-diones and analogues. This protocol provides a series of pyridones fused with saturated cycles with good functional group compatibility, good water and air tolerance, and good to excellent yields under mild and green reaction conditions. Additionally, scale-up synthesis can be smoothly performed with as low as 0.25 mol % catalyst loading. Recycling experiments and different transformation experiments were also carried out to demonstrate the potential synthetic utility of this protocol.
WOS关键词IODONIUM YLIDES ; ANNULATIONS ; CARBENES
资助项目National Natural Science Foundation of China[2021A1515110468] ; Basic and Applied Basic Research Foundation of Guangdong Province[21PJ1415800] ; Shanghai Pujiang Program[82204192] ; National Natural Science Foundation of China[BK20220471] ; Natural Science Foundation of Jiangsu Province[XPT82204192] ; Nanjing University of Chinese Medicine[2019B090904008] ; High-level new RD institute[2021B0909050003] ; High-level Innovative Research Institute
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001242692200001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/311579]  
专题中国科学院上海药物研究所
通讯作者Nian, Yong; Wu, Xiaowei
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
4.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China
5.Guangzhou Univ Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xueqing,Shi, Sijia,Ding, Wenqian,et al. Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C-H Activation/[4+2] Cyclization[J]. ORGANIC LETTERS,2024:5.
APA Liu, Xueqing.,Shi, Sijia.,Ding, Wenqian.,He, Zhiyue.,Shen, Yu.,...&Wu, Xiaowei.(2024).Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C-H Activation/[4+2] Cyclization.ORGANIC LETTERS,5.
MLA Liu, Xueqing,et al."Accessing 7,8-Dihydroquinoline-2,5-diones via Rh-Catalyzed Olefinic C-H Activation/[4+2] Cyclization".ORGANIC LETTERS (2024):5.

入库方式： OAI收割

来源：上海药物研究所

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