Lauinoids A-X: Labdane-type diterpenoids with anti-inflammatory activity from Croton laui
文献类型：期刊论文
| 作者 | Zhang, Zong-Yi2,3; Li, Ying1; Yu, Jin-Hai1; Zhao, Jin-Xin1,3; Yue, Jian-Min1,2,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2024-07-01 |
| 卷号 | 223页码:16 |
| 关键词 | Croton laui Euphorbiaceae Diterpenoid Labdane Lauinoids A-X Anti-inflammatory |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114138 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Croton laui (Euphorbiaceae) is a traditional medicinal plant used by the Li ethnic group in China to treat headaches, stomachaches, and diphtheria. To understand the pharmacological basis of its medicinal use, an extensive investigation of the ethanolic extract of the bark of C. laui was performed. After repeated chromatography, twenty-four undescribed labdane-type diterpenoids, lauinoids A-X (1-24), and five known analogs (25-29) were isolated. Their structures and absolute configurations were established using a combination of spectroscopic analyses, electronic circular dichroism, nuclear magnetic resonance calculations, and single -crystal X-ray diffraction. Among them, compounds 1-3 exhibited an 11(12 -> 13)-abeo-16-nor-labdane skeleton, which originated putatively from 9 through a plausible pathway that involves a semipinacol rearrangement process. Compounds 11 and 12 belong to the rare class of 14,15-dinor-labdane diterpenoids. Compounds 18 and 28 exhibited substantial inhibitory effects by suppressing lipopolysaccharide-induced NO production in RAW 264.7 macrophages, with IC50 values of 3.37 +/- 0.23 and 5.82 +/- 0.28 mu M, respectively. This study has greatly expanded the chemical diversity of labdane diterpenoids from C. laui and will guide future research on this ethnomedicinal plant. |
| WOS关键词 | ELECTRONIC CIRCULAR-DICHROISM ; LEAVES |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[T2192972] ; Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)[2022282] ; Shanghai Pujiang Program[22PJ1415800] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001243340400001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311597]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, 198 East Binhai Rd, Yantai 264117, Shandong, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zong-Yi,Li, Ying,Yu, Jin-Hai,et al. Lauinoids A-X: Labdane-type diterpenoids with anti-inflammatory activity from Croton laui[J]. PHYTOCHEMISTRY,2024,223:16. |
| APA | Zhang, Zong-Yi,Li, Ying,Yu, Jin-Hai,Zhao, Jin-Xin,&Yue, Jian-Min.(2024).Lauinoids A-X: Labdane-type diterpenoids with anti-inflammatory activity from Croton laui.PHYTOCHEMISTRY,223,16. |
| MLA | Zhang, Zong-Yi,et al."Lauinoids A-X: Labdane-type diterpenoids with anti-inflammatory activity from Croton laui".PHYTOCHEMISTRY 223(2024):16. |
入库方式： OAI收割
来源：上海药物研究所
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