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Rhodium-Promoted C-H Activation/Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes

文献类型：期刊论文

作者Lv, Yuhan5,6; Wu, Min3,4; Lu, Weiwei5; Cui, Meiying2; Liu, Jiaxiang2; Yi, Wei3,4; Wang, Xuan2; Lu, Xiaojie1,5
刊名ORGANIC LETTERS
出版日期2024-06-04
卷号26期号:23页码:4958-4962
ISSN号1523-7060
DOI10.1021/acs.orglett.4c01553
通讯作者Yi, Wei(yiwei@gzhmu.edu.cn) ; Wang, Xuan(wangxuan@aiphama.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn)
英文摘要Inspired by previous selection outcomes, we investigated and developed a rhodium-promoted C-H activation/annulation reaction of DNA-linked terminal alkynes and aromatic acids. This reaction exhibits excellent efficiency with high conversions and a broad substrate scope. Most importantly, the unique DEL-compatible conditions provide a better scenario for yielding an isocoumarin scaffold compared to conventional organic reaction conditions, and this newly developed on-DNA method has confirmed its feasibility in preparing DNA-encoded libraries.
资助项目National Natural Science Foundation of China[NSFC-91953203] ; National Natural Science Foundation of China[NSFC-92253305] ; National Natural Science Foundation of China[SIMM0220233001] ; National Natural Science Foundation of China[82273795]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001239400300001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/311600]  
专题新药研究国家重点实验室
通讯作者Yi, Wei; Wang, Xuan; Lu, Xiaojie
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Alphama Biotechnol Suzhou Co Ltd, Suzhou City 215123, Jiangsu Provinc, Peoples R China
3.Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China
4.Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Mol, NMPA, Guangzhou 511436, Guangdong, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.Shandong Second Med Univ, Weifang 261053, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Yuhan,Wu, Min,Lu, Weiwei,et al. Rhodium-Promoted C-H Activation/Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes[J]. ORGANIC LETTERS,2024,26(23):4958-4962.
APA Lv, Yuhan.,Wu, Min.,Lu, Weiwei.,Cui, Meiying.,Liu, Jiaxiang.,...&Lu, Xiaojie.(2024).Rhodium-Promoted C-H Activation/Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes.ORGANIC LETTERS,26(23),4958-4962.
MLA Lv, Yuhan,et al."Rhodium-Promoted C-H Activation/Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes".ORGANIC LETTERS 26.23(2024):4958-4962.

入库方式： OAI收割

来源：上海药物研究所

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