Systematic Structural Modification of Squaraine Dye for Near-Infrared Window One and Two Multiplexed In Vivo Imaging and Photothermal Therapy
文献类型：期刊论文
| 作者 | Song, Ruihu4,5; Dong, Yiyun3; Zhong, Zhuoyi3; Zhao, Qi3; Hu, Yue3; Lei, Meiling3,5; Lei, Peng5; Jiang, Zhaoning4,5; Qian, Kun5; Shi, Chenchen5 |
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2024-06-06 |
| 页码 | 18 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.4c00601 |
| 通讯作者 | Chen, Hao(haoc@simm.ac.cn) |
| 英文摘要 | Due to the wide application of reporter gene-related visible/NIR-I bioluminescent imaging, multiplexed fluorescence imaging across visible/NIR-I/NIR-II has excellent potential in biomedical research. However, in vivo multiplexed imaging applications across those regions have rarely been reported due to the lack of proper fluorophores. Herein, nine squaraine dyes, which exhibit diverse adsorption and emission wavelengths, were synthesized. Among them, water-soluble SQ 710-5k and SQ 905 were found to have significant absorption differences, which allowed the tumor and lymph nodes to be identified. Then, for the first time, six-channel multiplexed fluorescence imaging across visible/NIR-I/II was achieved by coordination with reporter gene-related bioluminescent phosphors. Additional research revealed that SQ 710-5k exhibited higher-quality blood vessels and tumor imaging in NIR-II. H-aggregates SQ 905 demonstrated a high photothermal conversion efficiency for photothermal therapy. This study proposed an approach to creating small molecular dyes that coordinate with reporter gene-related bioluminescent phosphors for six-color fluorescence imaging. |
| WOS关键词 | NANOPARTICLES ; FLUORESCENCE ; LIFETIME ; PROTEIN ; PROBES ; TUMOR |
| 资助项目 | National Natural Science Foundation of China[82071976] ; National Natural Science Foundation of China[82102110] ; National Natural Science Foundation of China[CSTB2023TIAD-STX0006] ; Science and Technology Innovation Key R&D Program of Chongqing[YDZX20233100004032001] ; Science and Technology Commission of Shanghai Municipality[2023YFA1800804] ; National Key Research and Development Program of China[2021ZD0203900] ; National Key Research and Development Program of China[LG-QS-202206-01] ; National Science and Technology Innovation 2030 Major Project of China[JLSWSRCZX2020-0029] ; Finance Department of Jilin Province |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001242833700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311612]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Hao |
| 作者单位 | 1.Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Pharm Dept, Shanghai 201399, Peoples R China 2.First Hosp Jilin Univ, Radiol Dept, Changchun 130021, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Ruihu,Dong, Yiyun,Zhong, Zhuoyi,et al. Systematic Structural Modification of Squaraine Dye for Near-Infrared Window One and Two Multiplexed In Vivo Imaging and Photothermal Therapy[J]. JOURNAL OF MEDICINAL CHEMISTRY,2024:18. |
| APA | Song, Ruihu.,Dong, Yiyun.,Zhong, Zhuoyi.,Zhao, Qi.,Hu, Yue.,...&Chen, Hao.(2024).Systematic Structural Modification of Squaraine Dye for Near-Infrared Window One and Two Multiplexed In Vivo Imaging and Photothermal Therapy.JOURNAL OF MEDICINAL CHEMISTRY,18. |
| MLA | Song, Ruihu,et al."Systematic Structural Modification of Squaraine Dye for Near-Infrared Window One and Two Multiplexed In Vivo Imaging and Photothermal Therapy".JOURNAL OF MEDICINAL CHEMISTRY (2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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