Prognostic significance of serum tumor markers in various pathologic subtypes of gastric cancer
文献类型：期刊论文
| 作者 | Pang, Chuhong4; Ma, Yubo3; Shi, Wenyi1,2,4; Zi, Mengli4; Chen, Jinxia4; Liang, Chen4; Li, Xiao3; Liu, Zhuo3; Du, Yian3 |
| 刊名 | JOURNAL OF GASTROINTESTINAL SURGERY
 |
| 出版日期 | 2024-05-01 |
| 卷号 | 28期号:5页码:694-702 |
| 关键词 | Gastric adenocarcinoma Gastric cancer Gastric signet ring cell carcinoma Prognosis Serum tumor markers |
| ISSN号 | 1091-255X |
| DOI | 10.1016/j.gassur.2024.02.023 |
| 通讯作者 | Liu, Zhuo(Zhuoliu1985@126.com) |
| 英文摘要 | Purpose: This study aimed to assess the utility of 6 serum tumor markers in prognosis between gastric adenocarcinoma and gastric signet ring cell carcinoma (SRCC). Methods: A cohort of 3131 cases of gastric adenocarcinoma and 275 cases of gastric SRCC was assembled. The serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125, alpha fetoprotein (AFP), carbohydrate antigen 242 (CA242), and carbohydrate antigen 724 (CA724) were measured in all cases. The study analyzed the association between the levels of these 6 tumor markers and the prognosis of gastric adenocarcinoma and SRCC. Results: The study revealed that gastric SRCC exhibited lower concentrations of CEA (P < .001) and CA19-9 (P = .002), along with reduced positive rates of CEA (P = .041), CA19-9 (P = .003), AFP (P < .001), and CA242 (P = .006), while displaying higher positive rates of CA724 (P = .024) than gastric adenocarcinoma. Nevertheless, the receiver operating characteristic curve demonstrated that serum tumor markers did not hold clinical significance in differentiating between gastric adenocarcinoma and SRCC. Survival analysis substantiated that the combined criteria of serum tumor markers stood as an independent risk factor for both gastric adenocarcinoma and SRCC. Notably, the nomogram indicated that serum tumor markers exerted a more substantial influence on the prognosis of gastric adenocarcinoma than on gastric SRCC. Conclusion: The study concluded that the combined criteria of serum tumor markers emerge as independent risk factors for both subtypes of gastric cancer. Furthermore, this combined approach exhibited enhanced efficacy in prognosticating the outcome of gastric adenocarcinoma compared with gastric SRCC. (c) 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved. |
| WOS关键词 | CLINICAL-SIGNIFICANCE ; ALPHA-FETOPROTEIN ; CA-19-9 ; CEA ; AFP |
| 资助项目 | National Key R&D Program of China[2021YFA0910100] ; National Natural Science Foundation of China[82074245] ; National Natural Science Foundation of China[81973634] ; National Natural Science Foundation of China[82204828] ; Chinese Postdoctoral Science Foundation[2022M713203] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2018ZY006] ; Medical Science and Technology Project of Zhejiang Province[2022KY114] ; Medical Science and Technology Project of Zhejiang Province[WKJ-ZJ-2104] ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer[JBZX-202006] ; Natural Science Foundation of Zhejiang Province[HDMY22H160008] ; Science and Technology Projects of Zhejiang Province[2019C03049] |
| WOS研究方向 | Gastroenterology & Hepatology ; Surgery |
| 语种 | 英语 |
| WOS记录号 | WOS:001240041200001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311615]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Zhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Mol Med, Hangzhou, Peoples R China 3.Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Hangzhou, Zhejiang, Peoples R China 4.Wenzhou Med Univ, Zhejiang Canc Hosp, Postgrad Training Base Alliance, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pang, Chuhong,Ma, Yubo,Shi, Wenyi,et al. Prognostic significance of serum tumor markers in various pathologic subtypes of gastric cancer[J]. JOURNAL OF GASTROINTESTINAL SURGERY,2024,28(5):694-702. |
| APA | Pang, Chuhong.,Ma, Yubo.,Shi, Wenyi.,Zi, Mengli.,Chen, Jinxia.,...&Du, Yian.(2024).Prognostic significance of serum tumor markers in various pathologic subtypes of gastric cancer.JOURNAL OF GASTROINTESTINAL SURGERY,28(5),694-702. |
| MLA | Pang, Chuhong,et al."Prognostic significance of serum tumor markers in various pathologic subtypes of gastric cancer".JOURNAL OF GASTROINTESTINAL SURGERY 28.5(2024):694-702. |
入库方式： OAI收割
来源：上海药物研究所
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