Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton
文献类型：期刊论文
| 作者 | Wu, Wen-Kai9,10; Nie, Gui-Bin9,10; Lin, Jia-Ling8,9,10; Huang, Jia-Fa9,10; Guo, Xiao-Xiang10; Chen, Mei10; Fang, Xin7; Mao, Ying-Bo10; Li, Yan5,6; Wang, Ling-Jian10 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2024-06-05 |
| 页码 | 11 |
| 关键词 | cotton jasmonate pigment gland VQ domain |
| DOI | 10.1002/advs.202403059 |
| 通讯作者 | Huang, Jin-Quan(huangjinquan@cemps.ac.cn) |
| 英文摘要 | Plants have evolved diverse defense mechanisms encompassing physical and chemical barriers. Cotton pigment glands are known for containing various defense metabolites, but the precise regulation of gland size to modulate defense compound levels remains enigmatic. Here, it is discovered that the VQ domain-containing protein JAVL negatively regulates pigment gland size and the biosynthesis of defense compounds, while the MYC2-like transcription factor GoPGF has the opposite effect. Notably, GoPGF directly activates the expression of JAVL, whereas JAVL suppresses GoPGF transcription, establishing a negative feedback loop that maintains the expression homeostasis between GoPGF and JAVL. Furthermore, it is observed that JAVL negatively regulates jasmonate levels by inhibiting the expression of jasmonate biosynthetic genes and interacting with GoPGF to attenuate its activation effects, thereby maintaining homeostatic regulation of jasmonate levels. The increased expression ratio of GoPGF to JAVL leads to enlarged pigment glands and elevated jasmonates and defense compounds, enhancing insect and pathogen resistance in cotton. These findings unveil a new mechanism for regulating gland size and secondary metabolites biosynthesis, providing innovative strategies for strengthening plant defense. This study elucidates a negative feedback loop model involving a VQ-domain containing protein and a MYC2-like protein, whereby the ratio of their mRNA and protein contents regulates the size of pigment glands and the biosynthesis of secondary metabolites in cotton. These discoveries unveil a novel mechanism and present innovative strategies for enhancing plant defense, paving the avenue for the improvement of crops. image |
| WOS关键词 | PIGMENT GLANDS ; HISAT |
| 资助项目 | STI ; Biological Breeding of Stress tolerant and High Yield Cotton Varieties[2023ZD04040] ; National Natural Science Foundation of China[32388201] ; National Natural Science Foundation of China[32300330] ; National Key R&D Program of China[2022YFF1001400] ; Yunnan Revitalization Talent Support Program Top Team Project[202305AT350001] ; Yunnan Revitalization Talent Support Program Top Team Project[GMLM2023] ; Talent Plan of Shanghai Branch, Chinese Academy of Sciences[CASSHB-QNPD-2023-015] ; Foundation of Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Taishan Scholars Program[tsqn202312303] ; Shanghai Rising-Star Project[23QA1410100] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001241598500001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311624]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Jin-Quan |
| 作者单位 | 1.Chinese Acad Agr Sci, Western Agr Res Ctr, Changji 831100, Xinjiang, Peoples R China 2.Chinese Acad Agr Sci, Inst Cotton Res, Natl Key Lab Cotton Biobreeding & Integrated Utili, Anyang 455000, Henan, Peoples R China 3.Univ Nottingham, Sch Biosci, Dept Plant & Crop Sci, Sutton Bonington campus, Nottingham LE12 5RD, England 4.Xianghu Lab, Hangzhou 311231, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650204, Peoples R China 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Wen-Kai,Nie, Gui-Bin,Lin, Jia-Ling,et al. Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton[J]. ADVANCED SCIENCE,2024:11. |
| APA | Wu, Wen-Kai.,Nie, Gui-Bin.,Lin, Jia-Ling.,Huang, Jia-Fa.,Guo, Xiao-Xiang.,...&Huang, Jin-Quan.(2024).Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton.ADVANCED SCIENCE,11. |
| MLA | Wu, Wen-Kai,et al."Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton".ADVANCED SCIENCE (2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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