Peripheral nervous system lymphatic vessels: A simple delivery route to promote nerve regeneration
文献类型：期刊论文
| 作者 | Li, Senrui5; Li, Jiangnan5; Yang, Xiaoqi4,5; Huang, Jinsheng5; Feng, Shuai3; Xie, Zhenjun3; Yang, Ningning2; Wang, Yuanyi1; Zhou, Nan5 |
| 刊名 | EXPERIMENTAL NEUROLOGY
 |
| 出版日期 | 2024-07-01 |
| 卷号 | 377页码:17 |
| 关键词 | Lymphatic vessels Peripheral nerves Delivery routes Exosomes Nerve regenerations |
| ISSN号 | 0014-4886 |
| DOI | 10.1016/j.expneurol.2024.114783 |
| 通讯作者 | Yang, Ningning(yangningningzzu@126.com) ; Wang, Yuanyi(wangyuanyi@jlu.edu.cn) ; Zhou, Nan(fcczhoun@zzu.edu.cn) |
| 英文摘要 | The structural and functional features of lymphatic vessels in the peripheral nervous system (pLVs) is still unclear. Here, we clarify the existence of pLVs in rats, PROX1-EGFP transgenic mice and human, and exhibit a clear three-dimensional structure for helping understand its structural features. Moreover, two specific phenotypes of lymphatics endothelial cells (Rnd1 Hi LECs and Ccl21 Hi LECs) in peripheral nerves are well characterized by single -cell sequencing. Subsequently, the ability of trans -lymphatic delivery to peripheral nerves via pLVs has been dynamically demonstrated. After peripheral nerve injury (PNI), extensive lymphangiogenesis occurs in the lesion area and further enhances the efficiency of retrograde lymphatic -nerve transport. In PNI animal models, subcutaneously footpad -injected exosomes are efficiently delivered to sciatic nerve via pLVs which can promote nerve regeneration. The trans -lymphatic delivery to peripheral nerves via pLVs can subtly bypass BNB which provides an easy and alternative delivery route for PNI treatment. |
| WOS关键词 | SMALL EXTRACELLULAR VESICLES ; DRAINAGE ; BRAIN ; RND1 ; EXOSOMES ; CELLS |
| 资助项目 | National Natural Science Foundation of China[82071388] ; National Natural Science Foundation of China[82372498] ; Excellent Youth Science Foundation of Henan Province[212300410077] ; Young and middle-aged Health Science and Technology Innovation Talent of Henan Province[YXKC2020048] ; Key Research Project of Henan Educational Committee[21A320033] ; Medical Science and Technology Research Program of Henan Province[SBGJ202002118] ; Jilin Provincial Department of Science and Technology[20230204049YY] ; Norman Bethune Program of Jilin University[2022B04] ; Excellent Youth Science Foundation of Changchun[23YQ07] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001238978200001 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311627]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Ningning; Wang, Yuanyi; Zhou, Nan |
| 作者单位 | 1.Jilin Univ, First Hosp Jilin Univ, Orthoped Ctr, Dept Spinal Surg, Changchun 130021, Peoples R China 2.Zhengzhou Univ, Affiliated Hosp 1, Dept Emergency, Zhengzhou 450052, Peoples R China 3.Henan Prov Peoples Hosp, Dept Hand & Podiatr Surg, Zhengzhou 450000, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Zhengzhou Univ, Affiliated Hosp 1, Dept Orthoped, Zhengzhou 450052, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Senrui,Li, Jiangnan,Yang, Xiaoqi,et al. Peripheral nervous system lymphatic vessels: A simple delivery route to promote nerve regeneration[J]. EXPERIMENTAL NEUROLOGY,2024,377:17. |
| APA | Li, Senrui.,Li, Jiangnan.,Yang, Xiaoqi.,Huang, Jinsheng.,Feng, Shuai.,...&Zhou, Nan.(2024).Peripheral nervous system lymphatic vessels: A simple delivery route to promote nerve regeneration.EXPERIMENTAL NEUROLOGY,377,17. |
| MLA | Li, Senrui,et al."Peripheral nervous system lymphatic vessels: A simple delivery route to promote nerve regeneration".EXPERIMENTAL NEUROLOGY 377(2024):17. |
入库方式： OAI收割
来源：上海药物研究所
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