Real time monitoring peripheral nerve function with ICG and BDA-ICG by NIR-II fluorescence imaging
文献类型：期刊论文
| 作者 | Yang, Xiaoqi4,5; Wang, Yuanyi3; Qu, Chunrong4; Tan, Boyu4; Wang, Minjin2; Li, Senrui5; Huang, Jinsheng5; Li, Jiangnan5; Fang, Mengyuan1; Cheng, Zhen4 |
| 刊名 | MATERIALS TODAY BIO
 |
| 出版日期 | 2024-06-01 |
| 卷号 | 26页码:14 |
| ISSN号 | 2590-0064 |
| DOI | 10.1016/j.mtbio.2024.101084 |
| 通讯作者 | Fang, Mengyuan(fccfangmy@zzu.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) ; Zhou, Nan(fcczhoun@zzu.edu.cn) |
| 英文摘要 | Neuroanatomical tract tracers are important for studying axoplasmic transport and the complex interconnections of the nervous system. Though traditional fluorescent tracers are widely used, they have several prominent drawbacks when imaging, including low resolutions and low tissue penetrations and inability to be supervised dynamically within a long peripheral nerve during the long term. Here, we explored the potential of ICG as a neural tracer for axoplasmic transport and for the first time demonstrated that ICG could be used to detect transport function within peripheral nerve by near -infrared region II (NIR-II) imaging. On basis of this finding, a novel bi-directional neural tracer biotinylated dextran amine-indocyanine green (BDA-ICG) was prepared and characterized with better long-term stability and higher nerve -to -background ratio than ICG in vivo, and successfully imaged the injured peripheral nerve from the healthy one within 24 h. Our results show that BDA-ICG are promising neural tracers and clinically available dyes with NIR-II emission tail characteristics as ICG. |
| WOS关键词 | INDOCYANINE GREEN ICG ; DIAGNOSIS ; TRACER |
| 资助项目 | National Natural Science Foundation of China[82071388] ; National Natural Science Foundation of China[82372498] ; Excellent Youth Science Foundation of Henan Province[212300410077] ; Joint Fund for Science and Technology R&D Program of Henan Province[232301420063] ; Research fund for Overseas Returned Scholars of Human Resources and Social Security in Henan Province[2024-4-4] ; Excellent Youth Talent Program of Zhengzhou University (2023) ; Key Research Project of Henan Educational Committee[23A320063] ; International Cultivation of Henan Advanced Talents (ICHAT) program[2023-25-47] ; Medical Science and Technology Research Program of Henan Province[SBGJ202303034] ; Jilin Provincial Department of Science and Technology[20230204049YY] ; Excellent Youth Science Foundation of Changchun City (2023) ; Norman Bethune Program of Jilin University[2022B04] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001240308800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311633]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Fang, Mengyuan; Cheng, Zhen; Zhou, Nan |
| 作者单位 | 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou 450052, Peoples R China 2.Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu 610041, Peoples R China 3.First Hosp Jilin Univ, Jilin Univ, Orthoped Ctr, Dept Spinal Surg, Changchun 130021, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Zhengzhou Univ, Affiliated Hosp 1, Dept Orthoped, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaoqi,Wang, Yuanyi,Qu, Chunrong,et al. Real time monitoring peripheral nerve function with ICG and BDA-ICG by NIR-II fluorescence imaging[J]. MATERIALS TODAY BIO,2024,26:14. |
| APA | Yang, Xiaoqi.,Wang, Yuanyi.,Qu, Chunrong.,Tan, Boyu.,Wang, Minjin.,...&Zhou, Nan.(2024).Real time monitoring peripheral nerve function with ICG and BDA-ICG by NIR-II fluorescence imaging.MATERIALS TODAY BIO,26,14. |
| MLA | Yang, Xiaoqi,et al."Real time monitoring peripheral nerve function with ICG and BDA-ICG by NIR-II fluorescence imaging".MATERIALS TODAY BIO 26(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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