中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
A Spatially Stable Crystal-Particle Gel to Trap Patchouli Oil for Efficient Colonic Drug Delivery

文献类型：期刊论文

作者Guo, Ru4,5; Xu, Weihua3,4; Wang, Yingshu4,5; Yue, Lixia4,5; Huang, Shaogang2; Xiu, Yanfeng5; Huang, Yongzhuo4; Wang, Bing1,4,5
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2024-05-24
卷号16期号:22页码:29198-29209
关键词colitis patchouli patchouli oil oil gel intestinal permeability TRP channels oral delivery
ISSN号1944-8244
DOI10.1021/acsami.4c03219
通讯作者Xiu, Yanfeng(xiuyf@hotmail.com) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要Patchouli oil has exhibited remarkable efficacy in the treatment of colitis. However, its volatility and potential irritancy are often drawbacks when extensively used in clinical applications. Oil gel is a semisolid and thermoreversible system that has received extensive interest for its solubility enhancement, inhibition of bioactive component recrystallization, and the facilitation of controlled bioactive release. Therefore, we present a strategy to develop an oil gel formulation that addresses this multifaceted problem. Notably, a patchouli oil gel formulation was designed to solidify and trap patchouli oil into a spatially stable crystal-particle structure and colonic released delivery, which has an advantage of the stable structure and viscosity. The patchouli oil gel treatment of zebrafish with colitis improved goblet cells and decreased macrophages. Additionally, patchouli oil gel showed superior advantages for restoring the tissue barrier. Furthermore, our investigative efforts unveiled patchouli oil's influence on TRP channels, providing evidence for its potential role in mechanisms of anti-inflammatory action. While the journey continues, these preliminary revelations provide a robust foundation for considering the adoption of patchouli oil gel as a pragmatic intervention for managing colitis.
WOS关键词ANTIINFLAMMATORY ACTIVITY ; RELEASE ; MATRICES
资助项目National Natural Science Foundation of China[2021YFE0103100] ; National Natural Science Foundation of China[2022YFE0203600] ; National Key Research and Development Program of China[81925035] ; National Key Research and Development Program of China[82341232] ; National Natural Science Foundation of China[2019B09090400] ; National Natural Science Foundation of China[2021B0909050003] ; Department of Science and Technology of Guangdong Province (High-level Innovative Research Institute)[LJ2021001] ; Department of Science and Technology of Guangdong Province (High-level Innovative Research Institute)[CXTD2022011] ; Zhongshan Municipal Bureau of Science and Technology[CASIMM0120184002] ; Chinese Academy of Science at the Innovation Academy, China[PWZbr2022-11] ; Important weak disciplines of clinical pharmacy in Pudong New Area Health System[ZPRC-2023A-11] ; Talent Support Project of Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001231896100001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/311746]  
专题新药研究国家重点实验室
通讯作者Xiu, Yanfeng; Huang, Yongzhuo; Wang, Bing
作者单位1.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, State Key Lab Syst Med Canc,Sch Med, Shanghai 200032, Peoples R China
2.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 501405, Peoples R China
3.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Pharm, Shanghai 201318, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Ru,Xu, Weihua,Wang, Yingshu,et al. A Spatially Stable Crystal-Particle Gel to Trap Patchouli Oil for Efficient Colonic Drug Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16(22):29198-29209.
APA Guo, Ru.,Xu, Weihua.,Wang, Yingshu.,Yue, Lixia.,Huang, Shaogang.,...&Wang, Bing.(2024).A Spatially Stable Crystal-Particle Gel to Trap Patchouli Oil for Efficient Colonic Drug Delivery.ACS APPLIED MATERIALS & INTERFACES,16(22),29198-29209.
MLA Guo, Ru,et al."A Spatially Stable Crystal-Particle Gel to Trap Patchouli Oil for Efficient Colonic Drug Delivery".ACS APPLIED MATERIALS & INTERFACES 16.22(2024):29198-29209.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。