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Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism

文献类型：期刊论文

作者Feng, Huixu6,7; Liu, Guobin6,7; Li, Luhan4,5; Ren, Xuelian6; Jiang, Yue3,6; Hou, Wanting6; Liu, Ruilong6; Liu, Kun3; Liu, Hong4; Huang, He1,2,6,7
刊名ACS OMEGA
出版日期2024-05-29
卷号9期号:23页码:24308-24320
ISSN号2470-1343
DOI10.1021/acsomega.3c09983
通讯作者Huang, He(hhuang@simm.ac.cn)
英文摘要Hyperlipidemia (HLP) is a prevalent systemic metabolic disorder characterized by disrupted lipid metabolism. Statin drugs have long been the primary choice for managing lipid levels, but intolerance issues have prompted the search for alternative treatments. Matrine, a compound derived from the traditional Chinese medicine Kushen, exhibits anti-inflammatory and lipid-lowering properties. Nevertheless, the mechanism by which matrine modulates lipid metabolism remains poorly understood. Here, we investigated the molecular mechanisms underlying matrine's regulation of lipid metabolism. Employing quantitative proteomics, we discovered that matrine increases the expression of LDL receptor (LDLR) in HepG2 and A549 cells, with subsequent experiments validating its role in enhancing LDL uptake. Notably, in hyperlipidemic hamsters, matrine effectively lowered lipid levels without affecting body weight, which highlights LDLR as a critical target for matrine's impact on HLP. Moreover, matrine's potential inhibitory effects on tumor cell LDL uptake hint at broader applications in cancer research. Additionally, thermal proteome profiling analysis identified lipid metabolism-related proteins that may interact with matrine. Together, our study reveals matrine's capacity to upregulate LDLR expression and highlights its potential in treating HLP. These findings offer insights into matrine's mechanism of action and open new avenues for drug research and lipid metabolism regulation.
WOS关键词GENE ; MUTATIONS ; TRANSPORT ; DISEASE ; HEALTH ; CELLS ; ABCA1 ; HDL
资助项目Natural Science Foundation of Shanghai Municipality[22277125] ; Natural Science Foundation of Shanghai Municipality[92253306] ; National Natural Science Foundation of China[23ZR1474600] ; Natural Science Foundation of Shanghai[SYS202205] ; Shandong Laboratory Program ; Shanghai Municipal Science and Technology Major Project
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001236285700001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/311749]  
专题新药研究国家重点实验室
通讯作者Huang, He
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
3.Northeastern Univ, Sch Mech Engn & Automat, Shenyang 110819, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
7.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210203, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Huixu,Liu, Guobin,Li, Luhan,et al. Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism[J]. ACS OMEGA,2024,9(23):24308-24320.
APA Feng, Huixu.,Liu, Guobin.,Li, Luhan.,Ren, Xuelian.,Jiang, Yue.,...&Huang, He.(2024).Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism.ACS OMEGA,9(23),24308-24320.
MLA Feng, Huixu,et al."Quantitative Proteomics Reveal the Role of Matrine in Regulating Lipid Metabolism".ACS OMEGA 9.23(2024):24308-24320.

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来源：上海药物研究所

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