Towards chemoenzymatic labeling strategies for profiling protein glycosylation
文献类型：期刊论文
| 作者 | Tian, Yinping2,3; Ma, Shengzhou2,3; Wen, Liuqing1,2,3 |
| 刊名 | CURRENT OPINION IN CHEMICAL BIOLOGY
 |
| 出版日期 | 2024-06-01 |
| 卷号 | 80页码:14 |
| 关键词 | Chemoenzymatic labeling strategies Protein glycosylation Glyco-proteomics Mass spectrometry |
| ISSN号 | 1367-5931 |
| DOI | 10.1016/j.cbpa.2024.102460 |
| 通讯作者 | Wen, Liuqing(lwen@simm.ac.cn) |
| 英文摘要 | Protein glycosylation is one of the most common and important post-translational modifications of proteins involved in regulating glycoprotein functions. The chemoenzymatic glycan labeling strategy allows rapid, efficient, and selective interrogation of glycoproteins. Glycoproteomics identifies protein glycosylation events at a large scale, providing information such as peptide sequences, glycan structures, and glycosylated sites. This review discusses the recent development of chemoenzymatic labeling strategies for glycoprotein analysis, mainly including glycoprotein and glycosite profiling. Fur thermore, we highlight the chemoenzymatic enrichment approaches in mass spectrometry analysis for three classes of glycan modifications, including N-glycosylation, O-GlcNAcylation, and mucin-type O-glycosylation. Finally, we highlight the emerging trends in new tools and cutting-edge technologies available for glycoproteomic research. |
| WOS关键词 | GLCNAC-MODIFIED PEPTIDES ; LINKED GLYCOPEPTIDES ; N-ACETYLGLUCOSAMINE ; TN ANTIGEN ; ENRICHMENT ; IDENTIFICATION ; QUANTIFICATION ; GLYCOPROTEINS ; MECHANISMS ; CHEMISTRY |
| 资助项目 | National Natural Science Foundation of China[22007092] ; National Natural Science Foundation of China[22307127] ; Natural Science Foundation of Shanghai[22ZR1474000] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:001235685300001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/311770]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wen, Liuqing |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, State Key Lab Chem Biol, Shanghai, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Yinping,Ma, Shengzhou,Wen, Liuqing. Towards chemoenzymatic labeling strategies for profiling protein glycosylation[J]. CURRENT OPINION IN CHEMICAL BIOLOGY,2024,80:14. |
| APA | Tian, Yinping,Ma, Shengzhou,&Wen, Liuqing.(2024).Towards chemoenzymatic labeling strategies for profiling protein glycosylation.CURRENT OPINION IN CHEMICAL BIOLOGY,80,14. |
| MLA | Tian, Yinping,et al."Towards chemoenzymatic labeling strategies for profiling protein glycosylation".CURRENT OPINION IN CHEMICAL BIOLOGY 80(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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