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Purification of gamma-cyclodextrin via selective coordination with potassium ions to form metal-organic frameworks

文献类型：期刊论文

作者Baqing, Libumo3,6; He, Xiaojian3,4; Ni, Qijia3,6; Zhang, Hanwen2,5; Li, Tianfu2,3; Lin, Xueyuan2,3; Guo, Tao5; Garba, Bello Mubarak4; Chen, Xintao4; Zhang, Jiwen1,5,6
刊名CARBOHYDRATE POLYMERS
出版日期2024-08-15
卷号338页码:11
关键词Gamma-cyclodextrin Metal-organic framework Potassium ion Crystallization Purification
ISSN号0144-8617
DOI10.1016/j.carbpol.2024.122193
通讯作者Zhang, Jiwen(jwzhang@simm.ac.cn) ; Peng, Can(pengcan@ahtcm.edu.cn) ; Wang, Caifen(wangcaifen@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn)
英文摘要Efficient purification of gamma-cyclodextrin ( gamma- CD) is always challenging due to its structural similarity to other CDs and low crystallinity in water. In addressing this issue, an approach was proposed based on the formation mechanism of cyclodextrin metal-organic frameworks (CD-MOFs). This method involved the selective coordination of CDs mixture with potassium ions in water, facilitated by ethanol-induced crystallization, leading to the purification of gamma- CD. The results showed that potassium ions enhanced gamma- CD crystallization, and ethanol was crucial to selectively coordinating potassium ions with gamma- CD. The characterizations revealed that the resulting CD-MOFs exhibited a small particle size, high surface area, and high thermal stability, and was identical to gamma- CD- MOF, further indicating the final gamma- CD with high purity. The separation factors of gamma- CD/alpha-CD and gamma- CD/ 8- CD were 309 and 260, respectively. Moreover, this method was validated through its application to the industrial enzymatic CDs mixture. The purification of gamma- CD could achieve 99.99 +/- 0.01 % after four crystallization cycles. Therefore, selectively coordinating with potassium ions to form MOFs provided a valuable reference for the purification of gamma- CD and even the direct synthesis of gamma- CD-MOF from CDs mixture. This advancement will also benefit the future production and application of gamma- CD.
WOS关键词ENZYMATIC PRODUCTION ; GLYCOSYLTRANSFERASE ; CRYSTALLIZATION ; SOLUBILITY
资助项目National Natural Science Foundation of China[82273863]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:001237344500001
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/311797]  
专题中国科学院上海药物研究所
通讯作者Zhang, Jiwen; Peng, Can; Wang, Caifen; Wu, Li
作者单位1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
3.Yangtze Delta Drug Adv Res Inst, Haimen 226133, Jiangsu, Peoples R China
4.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
6.Anhui Univ Chinese Med, Hefei 230000, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Baqing, Libumo,He, Xiaojian,Ni, Qijia,et al. Purification of gamma-cyclodextrin via selective coordination with potassium ions to form metal-organic frameworks[J]. CARBOHYDRATE POLYMERS,2024,338:11.
APA Baqing, Libumo.,He, Xiaojian.,Ni, Qijia.,Zhang, Hanwen.,Li, Tianfu.,...&Wu, Li.(2024).Purification of gamma-cyclodextrin via selective coordination with potassium ions to form metal-organic frameworks.CARBOHYDRATE POLYMERS,338,11.
MLA Baqing, Libumo,et al."Purification of gamma-cyclodextrin via selective coordination with potassium ions to form metal-organic frameworks".CARBOHYDRATE POLYMERS 338(2024):11.

入库方式： OAI收割

来源：上海药物研究所

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