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Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery

文献类型：期刊论文

作者Zhu, Huajie5,6; Lv, Yuting5,6; Xin, Fangyuan4,5; Wang, Manli3; Zhao, Xiangyu5,6; Ren, Xiaohong2; Zhang, Jiwen1,2,3,4,5,6; Yin, Dengke6; Guo, Tao2; Wu, Li1,2,3,5,6
刊名AAPS PHARMSCITECH
出版日期2024-05-28
卷号25期号:5页码:16
关键词Eugenol Cyclodextrin metal-organic framework Solidification Nasal powder Stability
ISSN号1530-9932
DOI10.1208/s12249-024-02839-1
通讯作者Yin, Dengke(yindengke@ahtcm.edu.cn) ; Guo, Tao(guotao@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn)
英文摘要Eugenol (Eug) holds potential as a treatment for bacterial rhinosinusitis by nasal powder drug delivery. To stabilization and solidification of volatile Eug, herein, nasal inhalable gamma-cyclodextrin metal-organic framework (gamma-CD-MOF) was investigated as a carrier by gas-solid adsorption method. The results showed that the particle size of Eug loaded by gamma-CD-MOF (Eug@gamma-CD-MOF) distributed in the range of 10-150 mu m well. In comparison to gamma-CD and beta-CD-MOF, gamma-CD-MOF has higher thermal stability to Eug. And the intermolecular interactions between Eug and the carriers were verified by characterizations and molecular docking. Based on the bionic human nasal cavity model, Eug@gamma-CD-MOF had a high deposition distribution (90.07 +/- 1.58%). Compared with free Eug, the retention time Eug@gamma-CD-MOF in the nasal cavity was prolonged from 5 min to 60 min. In addition, the cell viability showed that Eug@gamma-CD-MOF (Eug content range 3.125-200 mu g/mL) was non-cytotoxic. And the encapsulation of gamma-CD-MOF could not reduce the bacteriostatic effect of Eug. Therefore, the biocompatible gamma-CD-MOF could be a potential and valuable carrier for nasal drug delivery to realize solidification and nasal therapeutic effects of volatile oils.
WOS关键词ANTIMICROBIAL ACTIVITY ; CHEMICAL-COMPOSITION ; THERMAL-STABILITY ; BETA-CYCLODEXTRIN ; ESSENTIAL OILS ; IN-VITRO ; CD-MOF ; DRUG ; BIOAVAILABILITY ; TEMPERATURE
资助项目National Natural Science Foundation of China[82273863]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001233945200002
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/311806]  
专题中国科学院上海药物研究所
通讯作者Yin, Dengke; Guo, Tao; Wu, Li
作者单位1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
3.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China
4.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
5.Yangtze Delta Drug Adv Res Inst, Nantong 226133, Jiangsu, Peoples R China
6.Anhui Univ Chinese Med, Hefei 230000, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Huajie,Lv, Yuting,Xin, Fangyuan,et al. Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery[J]. AAPS PHARMSCITECH,2024,25(5):16.
APA Zhu, Huajie.,Lv, Yuting.,Xin, Fangyuan.,Wang, Manli.,Zhao, Xiangyu.,...&Wu, Li.(2024).Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery.AAPS PHARMSCITECH,25(5),16.
MLA Zhu, Huajie,et al."Enhanced Stability and Solidification of Volatile Eugenol by Cyclodextrin-Metal Organic Framework for Nasal Powder Delivery".AAPS PHARMSCITECH 25.5(2024):16.

入库方式： OAI收割

来源：上海药物研究所

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