Four new phenolic compounds from the fruits of Alpinia galanga
文献类型：期刊论文
| 作者 | Liu,Pei; Wu,Sheng-Li; Wang,Tian; Zhang,Xue-Mei; Geng,Chang-An |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2023 |
| 卷号 | 55页码:75-79 |
| 关键词 | Alpinia galanga Phenolic compounds PTP1B inhibitory activity ?-glycosidase inhibitory activity GLP-1 secretion |
| ISSN号 | 1876-7486 |
| DOI | 10.1016/j.phytol.2023.04.001 |
| 英文摘要 | Eleven phenolic compounds including four new ones, (R)-4-(1-methoxypropyl)phenol (1), (S)-3-(4-hydroxy-3-methoxyphenyl)propane-1,2-diyldiacetate (2), (R)-3-(4-hydroxy-3-methoxyphenyl)propane-1,2-diyldiacetate (3) and 3 '-demethoxycrataegusanoid E (4), were isolated from the fruits of Alpinia galanga. The structures of new compounds were elucidated on the basis of extensive spectroscopic data (1D and 2D NMR, [alpha]D, HRESIMS, UV and IR). All the isolates were assayed for their antidiabetic potency against PTP1B and alpha-glycosidase enzymes, and glucagon-like peptide-1 (GLP-1) promotion. Compound 4 showed significant inhibition on PTP1B with an IC50 value of 58.4 mu M, and compound 6 showed alpha-glycosidase inhibitory activity with an IC50 value of 97.6 mu M. Compounds 1-4 and 7-11 could stimulate GLP-1 secretion in NCl-H716 cells with promoting rates of 770.5-1943.1 % (50 mu M). This study provides information for understanding the antidiabetic constituents of A. galanga. |
| 学科主题 | Plant Sciences ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000982454800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75424]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Liu,Pei,Wu,Sheng-Li,Wang,Tian,et al. Four new phenolic compounds from the fruits of Alpinia galanga[J]. PHYTOCHEMISTRY LETTERS,2023,55:75-79. |
| APA | Liu,Pei,Wu,Sheng-Li,Wang,Tian,Zhang,Xue-Mei,&Geng,Chang-An.(2023).Four new phenolic compounds from the fruits of Alpinia galanga.PHYTOCHEMISTRY LETTERS,55,75-79. |
| MLA | Liu,Pei,et al."Four new phenolic compounds from the fruits of Alpinia galanga".PHYTOCHEMISTRY LETTERS 55(2023):75-79. |
入库方式： OAI收割
来源：昆明植物研究所
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