Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis
文献类型：期刊论文
| 作者 | Wu,Zhaodi; Zhang,Xiaotian; Li,Qin; Tong,Qingyi; Yang,Jing ; Chen,Chunmei; Zhu,Hucheng; Zhang,Yonghui
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2023 |
| 卷号 | 10期号:14页码:3530-3536 |
| 关键词 | ENDOPHYTIC FUNGUS RING-SYSTEM DIMER |
| DOI | 10.1039/d3qo00565h |
| 英文摘要 | Amichalasines F-J (1-5), five new cytochalasan heterotrimers composed of two aspochalasins and one epicoccine unit, along with asperchalasine A (6), were isolated from Aspergillus micronesiensis. Their structures, including absolute configurations, were elucidated using extensive spectroscopic data, quantum chemical calculations, and single X-ray diffraction analyses. Compound 1 possesses a different fusion pattern between the aspochalasin and epicoccine unit compared with 6, resulting in a mirror-imaged epicoccine unit. Interestingly, compounds 2-4 also possess mirror-imaged core structures of 6, even though they have the same fusion pattern. Compounds 1, and 2-4 represent two new kinds of cytochalasan heterotrimers. Plausible biosynthetic pathways of 1-6 are proposed. Compounds 2-4 exhibited potent cytotoxic activities against six human cancer cell lines, and the IC50 values against HL60 ranged from 4.36 to 5.69 mu M. |
| 学科主题 | Chemistry |
| WOS记录号 | WOS:001004961600001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75435]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Wu,Zhaodi,Zhang,Xiaotian,Li,Qin,et al. Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis[J]. ORGANIC CHEMISTRY FRONTIERS,2023,10(14):3530-3536. |
| APA | Wu,Zhaodi.,Zhang,Xiaotian.,Li,Qin.,Tong,Qingyi.,Yang,Jing.,...&Zhang,Yonghui.(2023).Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis.ORGANIC CHEMISTRY FRONTIERS,10(14),3530-3536. |
| MLA | Wu,Zhaodi,et al."Amichalasines F-J: cytochalasan heterotrimers with mirror-imaged core structures from Aspergillus micronesiensis".ORGANIC CHEMISTRY FRONTIERS 10.14(2023):3530-3536. |
入库方式： OAI收割
来源：昆明植物研究所
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