Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization
文献类型：期刊论文
| 作者 | Zhou,Zhipeng; Deng,Tuo; Tao,Maixian; Lin,Lisha; Sun,Luyun; Song,Xuemei; Gao,Dongxiu; Li,Jixing; Wang,Zhongjuan; Wang,Xingzi |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2023 |
| 卷号 | 299页码:122141 |
| 关键词 | Diabetic wound healing Biomimetic hydrogels Glycosaminoglycan Inflammation suppression Macrophage polarization FOOT ULCERS HUMAN SKIN ACTIVATION MANAGEMENT RECEPTORS DRESSINGS EFFICACY SAFETY |
| ISSN号 | 1878-5905 |
| DOI | 10.1016/j.biomaterials.2023.122141 |
| 英文摘要 | Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication, but treating DFUs remains a challenge for the existing therapies are expensive and highly non-responsive. Recently, we discovered that a natural adhesive from snail mucus can promote skin wound healing. Herein, inspired by the finding, we developed a double-network hydrogel biomaterial that composed of snail glycosaminoglycan (AFG) and methacrylated gelatin (GelMA), in which AFG is the main bioactive component of snail mucus and GelMA provides a scaffold mimicking the proteins in snail mucus. The biomimetic hydrogel exhibited strong tissue adhesion, potent anti-inflammatory activity, and excellent biocompatibility. The biodegradable AFG/GelMA hydrogel markedly promoted chronic wound healing in both STZ-induced type 1 diabetic rat and db/db mouse models after a single treatment. Further mechanistic research showed that the hydrogel significantly attenuated inflammation by sequestrating pro-inflammatory cytokines, as well as downregulated their expression by inhibiting NF-kappa B signaling pathway, and it can also promote macrophage polarization to M2 phenotype. Taken together, the bioinspired hydrogel can effectively promote the transition of chronic wounds from inflammation to proliferation stage. These data suggest that the AFG/GelMA hydrogel is a promising therapeutic biomaterial for the treatment of chronic diabetic wounds. |
| 学科主题 | Engineering ; Materials Science |
| WOS记录号 | WOS:001007294100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75470]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhou,Zhipeng,Deng,Tuo,Tao,Maixian,et al. Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization[J]. BIOMATERIALS,2023,299:122141. |
| APA | Zhou,Zhipeng.,Deng,Tuo.,Tao,Maixian.,Lin,Lisha.,Sun,Luyun.,...&Wu,Mingyi.(2023).Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization.BIOMATERIALS,299,122141. |
| MLA | Zhou,Zhipeng,et al."Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization".BIOMATERIALS 299(2023):122141. |
入库方式： OAI收割
来源：昆明植物研究所
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