Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii
文献类型：期刊论文
| 作者 | Tan,Qian; Hu,Kun ; Li,Xiao-Nian; Yang,Xing-Zhi; Sun,Han-Dong; Puno,Pema-Tenzin
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 135页码:106512 |
| 关键词 | Isodon wardii ent-Kauranoids Cytotoxicity Apoptosis Cell cycle |
| ISSN号 | 1090-2120 |
| DOI | 10.1016/j.bioorg.2023.106512 |
| 英文摘要 | Twenty new ent-kaurane diterpenoids, wardiisins A-T (1-20), along with two previously undescribed artefactual compounds (21 and 22) and twelve known analogues (23-34), were isolated from the aerial part of Isodon wardii. Their structures were elucidated by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction, and most of them were found to bear unusual C-12 oxygenation. Compounds 4, 7, 8, 19, 20, 21 exhibited remarkable cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MDA-MB-231, and SW480, with IC50 values ranging from 0.3 to 5.2 mu M. Moreover, 7 was found to induce G2/M cell cycle arrest and promote apoptosis in SW480 cell lines. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000977905800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75477]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Tan,Qian,Hu,Kun,Li,Xiao-Nian,et al. Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii[J]. BIOORGANIC CHEMISTRY,2023,135:106512. |
| APA | Tan,Qian,Hu,Kun,Li,Xiao-Nian,Yang,Xing-Zhi,Sun,Han-Dong,&Puno,Pema-Tenzin.(2023).Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii.BIOORGANIC CHEMISTRY,135,106512. |
| MLA | Tan,Qian,et al."Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii".BIOORGANIC CHEMISTRY 135(2023):106512. |
入库方式： OAI收割
来源：昆明植物研究所
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