Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy
文献类型：期刊论文
| 作者 | Peng,Xingrong; Luo,Rongcan; Ran,Xiaoqian; Guo,Yarong; Yao,Yong-Gang; Qiu,Minghua
|
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 132页码:106375 |
| 关键词 | Ganoderma Ganoderma applanatum Triterpenoid Autophagy Tau pathology Alzheimer?s disease LANOSTANE-TYPE TRITERPENOIDS ALZHEIMERS-DISEASE FRUITING BODIES NEURODEGENERATION ACID |
| ISSN号 | 1090-2120 |
| DOI | 10.1016/j.bioorg.2023.106375 |
| 英文摘要 | Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring, were obtained from Ganoderma applanatum. Their structures were established through extensive spectroscopic ana -lyses, quantum chemical calculations, including calculated chemical shifts with DP4 + analysis and electronic circular dichroism (ECD). A plausible biosynthetic pathway for 1 and 2 was proposed. Furthermore, their roles in activating autophagy were investigated and the cellular assays showed that 1 and 2 can inhibit tau pathology by inducing autophagy, suggesting their potential against Alzheimer's disease (AD). |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000925324500001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75479]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Peng,Xingrong,Luo,Rongcan,Ran,Xiaoqian,et al. Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy[J]. BIOORGANIC CHEMISTRY,2023,132:106375. |
| APA | Peng,Xingrong,Luo,Rongcan,Ran,Xiaoqian,Guo,Yarong,Yao,Yong-Gang,&Qiu,Minghua.(2023).Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy.BIOORGANIC CHEMISTRY,132,106375. |
| MLA | Peng,Xingrong,et al."Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy".BIOORGANIC CHEMISTRY 132(2023):106375. |
入库方式： OAI收割
来源：昆明植物研究所
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