Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica
文献类型：期刊论文
| 作者 | Ma,Wen-Yi; Xie,Jing; Yu,Ling-Ling; Zhang,Shi-Juan; Ni,Wei; Yan,Huan; Liu,Hai-Yang
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2023 |
| 卷号 | 130页码:106268 |
| 关键词 | Ypsilandra thibetica Steroidal saponins Ypsilandrosides Z1-Z14 Hemostatic activity Structure-activity relationship SPIROSTANE GLYCOSIDES NMR-SPECTROSCOPY AGGREGATION SAPOGENINS SAPONINS |
| ISSN号 | 1090-2120 |
| DOI | 10.1016/j.bioorg.2022.106268 |
| 英文摘要 | The phytoconstituents of the fraction with hemostatic activity of the 70% aqueous ethanol extract of Ypsilandra thibetica Franch. were investigated. As a result, fourteen previously unreported spirostanol saponins, ypsilan-drosides Z1-Z14, and nine known analogues were isolated and characterized by MS, NMR, and chemical methods. Among them, ypsilandrosides Z1-Z4 (1-4) have a rare 12-O-beta-D-glucopyranosyl group, while ypsi-landrosides Z5-Z8 (5-8) possess a rare double bond between C-4 and C-5, and a hydroxyl or carbonyl located at the C-6. All isolates were further tested for their hemostatic activity. The results suggested that five spirostanol tetraglycosides show favorable inducing platelet aggregation activities. Among them, ypsilandroside G (16) displayed significant inducing platelet aggregation activity with an EC50 value of 57.17 mu M. Furthermore, the preliminary structure-activity relationship of these spirostanol glycosides' hemostatic activity was discussed. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000926474500006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75480]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Ma,Wen-Yi,Xie,Jing,Yu,Ling-Ling,et al. Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica[J]. BIOORGANIC CHEMISTRY,2023,130:106268. |
| APA | Ma,Wen-Yi.,Xie,Jing.,Yu,Ling-Ling.,Zhang,Shi-Juan.,Ni,Wei.,...&Liu,Hai-Yang.(2023).Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica.BIOORGANIC CHEMISTRY,130,106268. |
| MLA | Ma,Wen-Yi,et al."Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica".BIOORGANIC CHEMISTRY 130(2023):106268. |
入库方式： OAI收割
来源：昆明植物研究所
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