Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway
文献类型：期刊论文
| 作者 | Zhu,Yiying; Zhao,Zhangxun; Xue,Minggao; Wang,Dan; Su,Guifeng; Ju,Xiaoman; Yang,Qihong; Zhang,Shaohua; Fan,Dongmei; Zhu,Huifang |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2023 |
| 卷号 | 659页码:10-19 |
| 关键词 | Ciclopirox olamine Natural killer cells NKG2D ligands Immunotherapy LIGANDS RECEPTOR GROWTH |
| ISSN号 | 1090-2104 |
| DOI | 10.1016/j.bbrc.2023.03.062 |
| 英文摘要 | The activating receptor natural killer group 2D (NKG2D) expressed by Natural killer (NK) cells functions as a master-switch in governing the awakening status of NK cells. The NKG2D-mediated cytotoxicity has been declared to be related with the expression levels of NKG2D ligands (NKG2DLs) expressed on tumor cells. Therefore, selective induction of NKG2DLs could be a reliable approach to enhance the ef-ficacy of NK cell-mediated immunotherapy. Our existing study demonstrated that Ciclopirox Olamine (CPX), an off-patent antifungal agent, effectively elevated the expression of NKG2DLs on leukemia cells and sensitized leukemia cells to NK-cell mediated cytolysis. Induction of ROS production and AKT phosphorylation by CPX is essential for the up-regulation of NKG2DLs expressions. Inhibition of AKT by using AKT inhibitor MK2206 decreased both NKG2DLs expressions and NK cell cytotoxicity. These data indicated that increased sensitivity of CPX-treated leukemia cells to NK cell cytolysis was attributed to higher NKG2DLs expressions, resulting from activated AKT signaling pathway. Our findings support the ongoing development of CPX as an anti-tumor agent and suggest its promising immunotherapeutic value in the medication of leukemia.(c) 2023 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| WOS记录号 | WOS:000977422400001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75482]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Zhu,Yiying,Zhao,Zhangxun,Xue,Minggao,et al. Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2023,659:10-19. |
| APA | Zhu,Yiying.,Zhao,Zhangxun.,Xue,Minggao.,Wang,Dan.,Su,Guifeng.,...&Zhou,Hongyu.(2023).Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,659,10-19. |
| MLA | Zhu,Yiying,et al."Ciclopirox olamine sensitizes leukemia cells to natural killer cell-mediated cytolysis by upregulating NKG2DLs via the Akt signaling pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 659(2023):10-19. |
入库方式： OAI收割
来源：昆明植物研究所
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