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Association of clinical variables and thyroid-stimulating hormone with psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder with elevated fasting blood glucose: preliminary exploratory study with a large sample

文献类型：期刊论文

作者Yang, Qian2,3,4; Wang, Qianjin3,4; Peng, Pu3,4; Liu, Tieqiao3,4; Zhang, Xiangyang1
刊名BJPSYCH OPEN
出版日期2024-05-03
卷号10期号:3页码:6
关键词Depressive disorder first-episode and drug-na & iuml psychotic symptoms thyroid-stimulating hormone elevated fasting blood glucose ve
ISSN号2056-4724
DOI10.1192/bjo.2024.53
通讯作者Liu, Tieqiao(liutieqiao123@csu.edu.cn)
英文摘要Background Psychotic symptoms and elevated fasting blood glucose (FBG) are frequently observed in people with major depressive disorder (MDD), but there is a lack of research into this relationship within this cohort.Aims This study aimed to preliminarily explore the prevalence of psychotic symptoms and their predictors among patients with MDD and elevated FBG.Method This study enrolled 1718 patients with first-episode and drug-na & iuml;ve (FEDN) MDD. Sociodemographic data and physical and biochemical indicators were collected. Clinical symptoms were assessed with tools such as the Hamilton Rating Scale for Anxiety, Hamilton Rating Scale for Depression (HRSD) and Positive and Negative Syndrome Scale positive subscale.Results The odds ratio for psychotic symptoms in those with MDD and elevated FBG (18.7%) was 2.33 times higher than those with MDD without elevated FBG. Presence of psychotic symptoms was significantly correlated with HRSD score, suicide attempts, and total cholesterol and thyroid-stimulating hormone levels. The combination of HRSD score, suicide attempts and thyroid-stimulating hormone levels among patients with MDD and elevated FBG effectively distinguished between individuals with and without psychotic symptoms, achieving an area under the curve of 0.87.Conclusions Psychotic symptoms are frequently observed among FEDN MDD patients with elevated FBG, and depressive symptoms, suicide attempts and thyroid-stimulating hormone levels are related to psychotic symptoms in this cohort.
收录类别SCI
WOS关键词DIABETES-MELLITUS ; SCHIZOPHRENIA ; RISK ; CLASSIFICATION ; PREVALENCE ; DIAGNOSIS ; EPISODE ; ANXIETY ; SEX
资助项目Hunan Provincial Natural Science Foundation[2020JJ4795]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:001258432400001
出版者CAMBRIDGE UNIV PRESS
资助机构Hunan Provincial Natural Science Foundation
源URL[http://ir.psych.ac.cn/handle/311026/48336]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Liu, Tieqiao
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Zhongshan City Peoples Hosp, Dept Psychol, Zhongshan, Peoples R China
3.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha, Peoples R China
4.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Qian,Wang, Qianjin,Peng, Pu,et al. Association of clinical variables and thyroid-stimulating hormone with psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder with elevated fasting blood glucose: preliminary exploratory study with a large sample[J]. BJPSYCH OPEN,2024,10(3):6.
APA Yang, Qian,Wang, Qianjin,Peng, Pu,Liu, Tieqiao,&Zhang, Xiangyang.(2024).Association of clinical variables and thyroid-stimulating hormone with psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder with elevated fasting blood glucose: preliminary exploratory study with a large sample.BJPSYCH OPEN,10(3),6.
MLA Yang, Qian,et al."Association of clinical variables and thyroid-stimulating hormone with psychotic symptoms in patients with first-episode and drug-na?ve major depressive disorder with elevated fasting blood glucose: preliminary exploratory study with a large sample".BJPSYCH OPEN 10.3(2024):6.

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来源：心理研究所

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