Development and validation of a nomogram for suicide attempts in patients with first-episode drug-na?ve major depressive disorder
文献类型：期刊论文
| 作者 | Liu, Junjun2,3,4; Tong, Ruixiang4; Lu, Zhaomin4; Wang, Zhiye4; Wang, Yangchun4; Liu, Yang4 ; Yuan, Hsinsung4; Jia, Fengnan2; Zhang, Xiaobin2; Li, Zhe2
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| 刊名 | FRONTIERS IN PSYCHIATRY
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| 出版日期 | 2024-06-06 |
| 卷号 | 15页码:14 |
| 关键词 | validation nomogram predict suicide attempts major depressive disorder |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2024.1398733 |
| 通讯作者 | Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | Objective The risk of suicide can be decreased by accurately identifying high-risk suicide groups and implementing the right interventions. The aim of this study was to develop a nomogram for suicide attempts (SA) in patients with first-episode drug-na & iuml;ve (FEDN) major depressive disorder (MDD).Methods This study undertook a cross-sectional analysis of 1,718 patients diagnosed with FEDN MDD, providing comprehensive clinical data from September 2016 to December 2018. Data on anthropometric and sociodemographic factors were gathered, and the severity of depression and anxiety was evaluated using the 17-item Hamilton Depression Scale (HAMD-17) and the Hamilton Anxiety Scale (HAMA), respectively. Additionally, thyroid hormone levels, lipid profile parameters, and fasting blood glucose (FBG) were measured. Suicide attempt (SA) history was verified based on an amalgamation of medical records, patient interviews, and family interviews. Participants were randomly divided into a training group (70%, n = 1,204) and a validation group (30%, n = 514). In the training group, LASSO analysis and multivariate regression were used to identify variables associated with SA. A nomogram was then constructed using the identified risk factors to estimate the likelihood of SA within the training group. To assess the accuracy, the area under the receiver operating characteristic curve (AUC) was utilized, and calibration plots were employed to evaluate calibration. Additionally, decision curve analysis (DCA) was performed to assess the precision of the model. Finally, internal validation was carried out using the validation group.Results A practical nomogram has been successfully constructed, incorporating HAMD, HAMA, thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and systolic blood pressure (SBP) parameters, to estimate the probability of SA in Chinese patients diagnosed with FEDN MDD. The pooled area under the ROC for SA risk in both the training and validation groups was found to be 0.802 (95% CI: 0.771 to 0.832) and 0.821 (95% CI: 0.774 to 0.868), respectively. Calibration analysis revealed a satisfactory correlation between the nomogram probabilities and the actual observed probabilities. The clinical applicability of the nomogram was confirmed through decision curve analysis. To enhance accessibility for clinicians and researchers, an online version of the nomogram can be accessed at https://doctorjunjunliu.shinyapps.io/dynnomapp/.Conclusions We constructed and validated a nomogram for the early detection of FEDN MDD patients with a high risk of SA, thereby contributing to the implementation of effective suicide prevention programs. |
| 收录类别 | SCI |
| WOS关键词 | RISK-FACTORS ; 5-HT1A RECEPTORS ; ANXIETY DISORDERS ; DISEASE ; ASSOCIATION ; MULTICENTER ; INVOLVEMENT ; POPULATION ; ACTIVATION ; BEHAVIOR |
| 资助项目 | Suzhou Gusu Health Talents Scientific Research Project[GSWS2021053] ; Suzhou Gusu Health Talents Scientific Research Project[GSWS2019070] ; Key Diagnosis and treatment Program of Suzhou[LCZX202016] ; Key Diagnosis and treatment Program of Suzhou[Szlcyxzx202109] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK21216] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK20184] ; Medical Science and Technology Development Foundation, Nanjing Department of Health[YKK22264] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:001250229500001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Suzhou Gusu Health Talents Scientific Research Project ; Key Diagnosis and treatment Program of Suzhou ; Medical Science and Technology Development Foundation, Nanjing Department of Health |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48396]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Du, Xiangdong; Zhang, Xiangyang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou, Peoples R China 3.Soochow Univ, Suzhou, Peoples R China 4.Nanjing Meishan Hosp, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Junjun,Tong, Ruixiang,Lu, Zhaomin,et al. Development and validation of a nomogram for suicide attempts in patients with first-episode drug-na?ve major depressive disorder[J]. FRONTIERS IN PSYCHIATRY,2024,15:14. |
| APA | Liu, Junjun.,Tong, Ruixiang.,Lu, Zhaomin.,Wang, Zhiye.,Wang, Yangchun.,...&Zhang, Xiangyang.(2024).Development and validation of a nomogram for suicide attempts in patients with first-episode drug-na?ve major depressive disorder.FRONTIERS IN PSYCHIATRY,15,14. |
| MLA | Liu, Junjun,et al."Development and validation of a nomogram for suicide attempts in patients with first-episode drug-na?ve major depressive disorder".FRONTIERS IN PSYCHIATRY 15(2024):14. |
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来源：心理研究所
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