Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition
文献类型：期刊论文
| 作者 | Shao, Ximing6; Krieger-Redwood, Katya6; Zhang, Meichao4,5,6 ; Hoffman, Paul3; Lanzoni, Lucilla6; Leech, Robert2; Smallwood, Jonathan1; Jefferies, Elizabeth6
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2024-05-15 |
| 卷号 | 44期号:20页码:18 |
| 关键词 | activation and deactivation default mode network fMRI functional connectivity semantics |
| ISSN号 | 0270-6474 |
| DOI | 10.1523/JNEUROSCI.1907-23.2024 |
| 通讯作者 | Shao, Ximing(ximingshao93@gmail.com) ; Jefferies, Elizabeth(beth.jefferies@york.ac.uk) |
| 英文摘要 | The default mode network (DMN) typically deactivates to external tasks, yet supports semantic cognition. It comprises medial temporal (MT), core, and frontotemporal (FT) subsystems, but its functional organization is unclear: the requirement for perceptual coupling versus decoupling, input modality (visual/verbal), type of information (social/spatial), and control demands all potentially affect its recruitment. We examined the effect of these factors on activation and deactivation of DMN subsystems during semantic cognition, across four task -based human functional magnetic resonance imaging (fMRI) datasets, and localized these responses in whole -brain state space de fi ned by gradients of intrinsic connectivity. FT showed activation consistent with a central role across domains, tasks, and modalities, although it was most responsive to abstract, verbal tasks; this subsystem uniquely showed more " tuned " states characterized by increases in both activation and deactivation when semantic retrieval demands were higher. MT also activated to both perceptually coupled (scenes) and decoupled (autobiographical memory) tasks and showed stronger responses to picture associations, consistent with a role in scene construction. Core DMN consistently showed deactivation, especially to externally oriented tasks. These diverse contributions of DMN subsystems to semantic cognition were related to their location on intrinsic connectivity gradients: activation was closer to the sensory -motor cortex than deactivation, particularly for FT and MT, while activation for core DMN was distant from both visual cortex and cognitive control. These results reveal distinctive yet complementary DMN responses: MT and FT support different memory -based representations that are accessed externally and internally, while deactivation in core DMN is associated with demanding, external semantic tasks. |
| 收录类别 | SCI |
| WOS关键词 | DORSAL ATTENTION ; FUNCTIONAL CONNECTIVITY ; NEGATIVE BOLD ; RESTING-STATE ; NEURAL BASIS ; BRAIN ; FMRI ; ROBUST ; REGISTRATION ; CORTEX |
| 资助项目 | European Research Council[771863 - FLEXSEM] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001249410700003 |
| 出版者 | SOC NEUROSCIENCE |
| 资助机构 | European Research Council |
| 源URL | [http://ir.psych.ac.cn/handle/311026/48390]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Shao, Ximing; Jefferies, Elizabeth |
| 作者单位 | 1.Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada 2.Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Neuroimaging Sci, London SE5 9RT, England 3.Univ Edinburgh, Sch Philosophy Psychol & Language Sci, Edinburgh EH8 9JZ, Scotland 4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 6.Univ York, Dept Psychol, York YO10 5DD, England |
| 推荐引用方式 GB/T 7714 | Shao, Ximing,Krieger-Redwood, Katya,Zhang, Meichao,et al. Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition[J]. JOURNAL OF NEUROSCIENCE,2024,44(20):18. |
| APA | Shao, Ximing.,Krieger-Redwood, Katya.,Zhang, Meichao.,Hoffman, Paul.,Lanzoni, Lucilla.,...&Jefferies, Elizabeth.(2024).Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition.JOURNAL OF NEUROSCIENCE,44(20),18. |
| MLA | Shao, Ximing,et al."Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition".JOURNAL OF NEUROSCIENCE 44.20(2024):18. |
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来源：心理研究所
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