The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions
文献类型：期刊论文
| 作者 | Yang,Mei-Xia; Cheng,Edwin Hok-Chi; Ospondpant,Dusadee; Tung,Ka-Ki; Wang,Li-Song; Lin,Sheng-Ying; Lai,Queenie Wing-Sze; Wu,Qi-Yun; Xia,Ying-Jie; Leung,Ka-Wing |
| 刊名 | JOURNAL OF FUNCTIONAL FOODS
 |
| 出版日期 | 2023 |
| 卷号 | 107页码:105607 |
| 关键词 | Alzheimer's disease Inflammation Fibrillar A beta Lichen Lobaria pindarensis Depsidone IN-SILICO IDENTIFICATION INHIBITORS |
| ISSN号 | 2214-9414 |
| DOI | 10.1016/j.jff.2023.105607 |
| 英文摘要 | Lobaria pindarensis Rasanen is an edible and medicinal lichen found in the Himalayas that has been used as ethnomedicine for years to combat inflammation. The study aimed to evaluate the ability of L. pindarensis extracts and its main depsidones to suppress inflammation and A beta fibril formation in cultured cells induced by LPS or A beta 42. The mRNA and protein expressions of inflammatory cytokines were declined significantly by the applied herbal extracts and depsidones in the LPS/A beta-treated immune cells (p < 0.05 to p < 0.001). In addition, the extracts and depsidones of L. pindarensis showed enhancement of phagocytotic function of microglia and disassembling aggregated A beta fibrils in dose-dependent manners (p < 0.05 to p < 0.001). The study presents the first evidence that L. pindarensis extracts have the potential to suppress inflammation and A beta fibril protein aggregation, making it a promising candidate for developing health food supplements for Alzheimer's patients. |
| WOS记录号 | WOS:001037290100001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/75492]  |
| 专题 | 中国科学院昆明植物研究所 |
| 推荐引用方式 GB/T 7714 | Yang,Mei-Xia,Cheng,Edwin Hok-Chi,Ospondpant,Dusadee,et al. The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions[J]. JOURNAL OF FUNCTIONAL FOODS,2023,107:105607. |
| APA | Yang,Mei-Xia.,Cheng,Edwin Hok-Chi.,Ospondpant,Dusadee.,Tung,Ka-Ki.,Wang,Li-Song.,...&Tsim,Karl Wah-Keung.(2023).The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions.JOURNAL OF FUNCTIONAL FOODS,107,105607. |
| MLA | Yang,Mei-Xia,et al."The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions".JOURNAL OF FUNCTIONAL FOODS 107(2023):105607. |
入库方式： OAI收割
来源：昆明植物研究所
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